8ze0: Difference between revisions

Latest revision as of 06:17, 30 October 2024

Drosophila melanogaster gustatory receptor 64a(Gr64a) in apo state

Structural highlights

8ze0 is a 4 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 2.54Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GR64A_DROME One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. Required in combination with Gr64f to detect sucrose, maltose, and glucose.^[1] ^[2] ^[3] ^[4] ^[5] ^[6] ^[7]

References

↑ Jiao Y, Moon SJ, Montell C. A Drosophila gustatory receptor required for the responses to sucrose, glucose, and maltose identified by mRNA tagging. Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14110-5. PMID:17715294 doi:10.1073/pnas.0702421104
↑ Dahanukar A, Lei YT, Kwon JY, Carlson JR. Two Gr genes underlie sugar reception in Drosophila. Neuron. 2007 Nov 8;56(3):503-16. PMID:17988633 doi:10.1016/j.neuron.2007.10.024
↑ Jiao Y, Moon SJ, Wang X, Ren Q, Montell C. Gr64f is required in combination with other gustatory receptors for sugar detection in Drosophila. Curr Biol. 2008 Nov 25;18(22):1797-801. PMID:19026541 doi:10.1016/j.cub.2008.10.009
↑ Dus M, Min S, Keene AC, Lee GY, Suh GS. Taste-independent detection of the caloric content of sugar in Drosophila. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11644-9. PMID:21709242 doi:10.1073/pnas.1017096108
↑ Nishimura A, Ishida Y, Takahashi A, Okamoto H, Sakabe M, Itoh M, Takano-Shimizu T, Ozaki M. Starvation-induced elevation of taste responsiveness and expression of a sugar taste receptor gene in Drosophila melanogaster. J Neurogenet. 2012 Jun;26(2):206-15. PMID:22794108 doi:10.3109/01677063.2012.694931
↑ Mishra D, Miyamoto T, Rezenom YH, Broussard A, Yavuz A, Slone J, Russell DH, Amrein H. The molecular basis of sugar sensing in Drosophila larvae. Curr Biol. 2013 Aug 5;23(15):1466-71. PMID:23850280 doi:10.1016/j.cub.2013.06.028
↑ Ma D, Hu M, Yang X, Liu Q, Ye F, Cai W, Wang Y, Xu X, Chang S, Wang R, Yang W, Ye S, Su N, Fan M, Xu H, Guo J. Structural basis for sugar perception by Drosophila gustatory receptors. Science. 2024 Feb 23;383(6685):eadj2609. PMID:38305684 doi:10.1126/science.adj2609

Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Jiao Y, Moon SJ, Montell C. A Drosophila gustatory receptor required for the responses to sucrose, glucose, and maltose identified by mRNA tagging. Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14110-5. PMID:17715294 doi:10.1073/pnas.0702421104

[2] Dahanukar A, Lei YT, Kwon JY, Carlson JR. Two Gr genes underlie sugar reception in Drosophila. Neuron. 2007 Nov 8;56(3):503-16. PMID:17988633 doi:10.1016/j.neuron.2007.10.024

[3] Jiao Y, Moon SJ, Wang X, Ren Q, Montell C. Gr64f is required in combination with other gustatory receptors for sugar detection in Drosophila. Curr Biol. 2008 Nov 25;18(22):1797-801. PMID:19026541 doi:10.1016/j.cub.2008.10.009

[4] Dus M, Min S, Keene AC, Lee GY, Suh GS. Taste-independent detection of the caloric content of sugar in Drosophila. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11644-9. PMID:21709242 doi:10.1073/pnas.1017096108

[5] Nishimura A, Ishida Y, Takahashi A, Okamoto H, Sakabe M, Itoh M, Takano-Shimizu T, Ozaki M. Starvation-induced elevation of taste responsiveness and expression of a sugar taste receptor gene in Drosophila melanogaster. J Neurogenet. 2012 Jun;26(2):206-15. PMID:22794108 doi:10.3109/01677063.2012.694931

[6] Mishra D, Miyamoto T, Rezenom YH, Broussard A, Yavuz A, Slone J, Russell DH, Amrein H. The molecular basis of sugar sensing in Drosophila larvae. Curr Biol. 2013 Aug 5;23(15):1466-71. PMID:23850280 doi:10.1016/j.cub.2013.06.028

[7] Ma D, Hu M, Yang X, Liu Q, Ye F, Cai W, Wang Y, Xu X, Chang S, Wang R, Yang W, Ye S, Su N, Fan M, Xu H, Guo J. Structural basis for sugar perception by Drosophila gustatory receptors. Science. 2024 Feb 23;383(6685):eadj2609. PMID:38305684 doi:10.1126/science.adj2609

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8ze0 is ON HOLD  until Paper Publication
+==Drosophila melanogaster gustatory receptor 64a(Gr64a) in apo state==
+<StructureSection load='8ze0' size='340' side='right'caption='[[8ze0]], [[Resolution|resolution]] 2.54&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8ze0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ZE0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ZE0 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.54&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ze0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ze0 OCA], [https://pdbe.org/8ze0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ze0 RCSB], [https://www.ebi.ac.uk/pdbsum/8ze0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ze0 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/GR64A_DROME GR64A_DROME] One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. Required in combination with Gr64f to detect sucrose, maltose, and glucose.<ref>PMID:17715294</ref> <ref>PMID:17988633</ref> <ref>PMID:19026541</ref> <ref>PMID:21709242</ref> <ref>PMID:22794108</ref> <ref>PMID:23850280</ref> <ref>PMID:38305684</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Drosophila melanogaster]]
+[[Category: Large Structures]]
+[[Category: Chen QF]]
+[[Category: Chen RZ]]
+[[Category: Zhang R]]

8ze0: Difference between revisions

Latest revision as of 06:17, 30 October 2024

Drosophila melanogaster gustatory receptor 64a(Gr64a) in apo state

Structural highlights

Function

References

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