1sl0: Difference between revisions

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[[Image:1sl0.~~gif~~|left|200px]]

[[Image:1sl0.png|left|200px]]

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~~'''~~Ternary 3' complex of T7 DNA polymerase with a DNA primer/template containing a disordered cis-syn thymine dimer on the template and an incoming nucleotide~~'''~~

===Ternary 3' complex of T7 DNA polymerase with a DNA primer/template containing a disordered cis-syn thymine dimer on the template and an incoming nucleotide===

~~==Overview==~~

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~~Ultraviolet-induced DNA damage poses a lethal block to replication. To understand the structural basis for~~ this, we determined crystal structures of a replicative DNA polymerase from bacteriophage T7 in complex with nucleotide substrates and a DNA template containing a cis-syn cyclobutane pyrimidine dimer (CPD). When the 3' thymine is the templating base, the ~~CPD is rotated out of~~ the ~~polymerase active site and the fingers subdomain adopts an open orientation~~. ~~When the 5' thymine is the templating base~~, ~~the CPD lies within the polymerase active site~~ where ~~it base-pairs with~~ the incoming nucleotide and the 3' base of the primer, while the fingers are in a closed conformation. These structures reveal the basis for the strong block of DNA replication that is caused by this photolesion.

The line below this paragraph, {{ABSTRACT_PUBMED_15235589}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 15235589 is the PubMed ID number.

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==About this Structure==

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[[Category: Open]]

[[Category: Thymine dimer]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 08~~:50:09 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:29:25 2008''

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-[[Image:1sl0.gif|left|200px]]
+{{Seed}}
+[[Image:1sl0.png|left|200px]]
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 {{STRUCTURE_1sl0|  PDB=1sl0  |  SCENE=  }}
-'''Ternary 3' complex of T7 DNA polymerase with a DNA primer/template containing a disordered cis-syn thymine dimer on the template and an incoming nucleotide'''
+===Ternary 3' complex of T7 DNA polymerase with a DNA primer/template containing a disordered cis-syn thymine dimer on the template and an incoming nucleotide===
-==Overview==
+<!--
-Ultraviolet-induced DNA damage poses a lethal block to replication. To understand the structural basis for this, we determined crystal structures of a replicative DNA polymerase from bacteriophage T7 in complex with nucleotide substrates and a DNA template containing a cis-syn cyclobutane pyrimidine dimer (CPD). When the 3' thymine is the templating base, the CPD is rotated out of the polymerase active site and the fingers subdomain adopts an open orientation. When the 5' thymine is the templating base, the CPD lies within the polymerase active site where it base-pairs with the incoming nucleotide and the 3' base of the primer, while the fingers are in a closed conformation. These structures reveal the basis for the strong block of DNA replication that is caused by this photolesion.
+The line below this paragraph, {{ABSTRACT_PUBMED_15235589}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15235589 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15235589}}
 ==About this Structure==
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 [[Category: Open]]
 [[Category: Thymine dimer]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:50:09 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:29:25 2008''