1sl7: Difference between revisions

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[[Image:1sl7.jpg|left|200px]]
{{Seed}}
[[Image:1sl7.png|left|200px]]


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{{STRUCTURE_1sl7|  PDB=1sl7  |  SCENE=  }}  
{{STRUCTURE_1sl7|  PDB=1sl7  |  SCENE=  }}  


'''Crystal structure of calcium-loaded apo-obelin from Obelia longissima'''
===Crystal structure of calcium-loaded apo-obelin from Obelia longissima===




==Overview==
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The crystal structures of calcium-loaded apo-aequorin and apo-obelin have been determined at resolutions 1.7A and 2.2 A, respectively. A calcium ion is observed in each of the three EF-hand loops that have the canonical calcium-binding sequence, and each is coordinated in the characteristic pentagonal bipyramidal configuration. The calcium-loaded apo-protein retain the same compact scaffold and overall fold as the unreacted photoproteins containing the bound substrate, 2-hyroperoxycoelenterazine, and also the same as the Ca2+-discharged obelin bound with product, coleneteramide. Nevertheless, there are easily discerned shifts in both helix and loop regions, and the shifts are not the same between the two proteins. It is suggested that these photoproteins to sense Ca2+ concentration transients and to produce their bioluminescence response on the millisecond timescale. A mechanism of intrastructural transmission of the calcium signal is proposed.
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{{ABSTRACT_PUBMED_15689515}}


==About this Structure==
==About this Structure==
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[[Category: Southeast collaboratory for structural genomic]]
[[Category: Southeast collaboratory for structural genomic]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:50:33 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:34:52 2008''

Revision as of 03:34, 28 July 2008

File:1sl7.png

Template:STRUCTURE 1sl7

Crystal structure of calcium-loaded apo-obelin from Obelia longissima

Template:ABSTRACT PUBMED 15689515

About this Structure

1SL7 is a Single protein structure of sequence from Obelia longissima. Full crystallographic information is available from OCA.

Reference

All three Ca2+-binding loops of photoproteins bind calcium ions: the crystal structures of calcium-loaded apo-aequorin and apo-obelin., Deng L, Vysotski ES, Markova SV, Liu ZJ, Lee J, Rose J, Wang BC, Protein Sci. 2005 Mar;14(3):663-75. Epub 2005 Feb 2. PMID:15689515

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