1son: Difference between revisions

Line 1:

[[Image:1son.~~jpg~~|left|200px]]

[[Image:1son.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~ADENYLOSUCCINATE SYNTHETASE IN COMPLEX WITH THE NATURAL FEEDBACK INHIBITOR AMP~~'''~~

===ADENYLOSUCCINATE SYNTHETASE IN COMPLEX WITH THE NATURAL FEEDBACK INHIBITOR AMP===

~~==Overview==~~

<!--

~~(+)-Hydantocidin~~, ~~a recently discovered natural spironucleoside with potent herbicidal activity~~, ~~is shown to be a proherbicide that, after phosphorylation at~~ the ~~5' position, inhibits adenylosuccinate synthetase, an enzyme involved in de novo purine synthesis. The mode of binding of hydantocidin 5'-monophosphate~~ to the ~~target enzyme was analyzed by determining the crystal structure of the enzyme-inhibitor complex~~ at 2.~~6-A resolution~~. ~~It was found that adenylosuccinate synthetase binds the phosphorylated compound in the same fashion as it does adenosine 5'-monophosphate~~, the ~~natural feedback regulator of this enzyme~~. ~~This work provides the first crystal structure of a herbicide~~-~~target complex reported to date.~~

The line below this paragraph, {{ABSTRACT_PUBMED_8790347}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 8790347 is the PubMed ID number.

-->

==About this Structure==

Line 29:

Line 33:

[[Category: Purine nucleotide biosynthesis]]

[[Category: Synthetase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 08~~:57:31 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:35:36 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1son.jpg|left|200px]]
+{{Seed}}
+[[Image:1son.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1son|  PDB=1son  |  SCENE=  }}
-'''ADENYLOSUCCINATE SYNTHETASE IN COMPLEX WITH THE NATURAL FEEDBACK INHIBITOR AMP'''
+===ADENYLOSUCCINATE SYNTHETASE IN COMPLEX WITH THE NATURAL FEEDBACK INHIBITOR AMP===
-==Overview==
+<!--
-(+)-Hydantocidin, a recently discovered natural spironucleoside with potent herbicidal activity, is shown to be a proherbicide that, after phosphorylation at the 5' position, inhibits adenylosuccinate synthetase, an enzyme involved in de novo purine synthesis. The mode of binding of hydantocidin 5'-monophosphate to the target enzyme was analyzed by determining the crystal structure of the enzyme-inhibitor complex at 2.6-A resolution. It was found that adenylosuccinate synthetase binds the phosphorylated compound in the same fashion as it does adenosine 5'-monophosphate, the natural feedback regulator of this enzyme. This work provides the first crystal structure of a herbicide-target complex reported to date.
+The line below this paragraph, {{ABSTRACT_PUBMED_8790347}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 8790347 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_8790347}}
 ==About this Structure==
@@ Line 29: / Line 33: @@
 [[Category: Purine nucleotide biosynthesis]]
 [[Category: Synthetase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:57:31 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:35:36 2008''