1sp0: Difference between revisions

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[[Image:1sp0.jpg|left|200px]]
{{Seed}}
[[Image:1sp0.png|left|200px]]


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{{STRUCTURE_1sp0|  PDB=1sp0  |  SCENE=  }}  
{{STRUCTURE_1sp0|  PDB=1sp0  |  SCENE=  }}  


'''Solution Structure of apoCox11'''
===Solution Structure of apoCox11===




==Overview==
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Cytochrome c oxidase assembly process involves many accessory proteins including Cox11, which is a copper-binding protein required for Cu incorporation into the Cu(B) site of cytochrome c oxidase. In a genome wide search, a number of Cox11 homologs are found in all of the eukaryotes with complete genomes and in several Gram-negative bacteria. All of them possess a highly homologous soluble domain and contain an N-terminal fragment that anchors the protein to the membrane. An anchor-free construct of 164 amino acids was obtained from Sinorhizobium meliloti, and the first structure of this class of proteins is reported here. The apoform has an immunoglobulin-like fold with a novel type of beta-strand organization. The copper binding motif composed of two highly conserved cysteines is located on one side of the beta-barrel structure. The apoprotein is monomeric in the presence of dithiothreitol, whereas it dimerizes in the absence of the reductant. When copper(I) binds, NMR and extended x-ray absorption fine structure (EXAFS) data indicate a dimeric protein state with two thiolates bridging two copper(I) ions. The present results advance the knowledge on the poorly understood molecular aspects of cytochrome c oxidase assembly.
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{{ABSTRACT_PUBMED_15181013}}


==About this Structure==
==About this Structure==
1SP0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sinorhizobium_meliloti Sinorhizobium meliloti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SP0 OCA].  
1SP0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sinorhizobium_meliloti Sinorhizobium meliloti]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SP0 OCA].  


==Reference==
==Reference==
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[[Category: Cytochrome c oxidase assembly]]
[[Category: Cytochrome c oxidase assembly]]
[[Category: Immunoglobulin-like fold]]
[[Category: Immunoglobulin-like fold]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:58:15 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:17:27 2008''

Revision as of 23:17, 28 July 2008

File:1sp0.png

Template:STRUCTURE 1sp0

Solution Structure of apoCox11

Template:ABSTRACT PUBMED 15181013

About this Structure

1SP0 is a Single protein structure of sequence from Sinorhizobium meliloti. Full experimental information is available from OCA.

Reference

Solution structure of Cox11, a novel type of beta-immunoglobulin-like fold involved in CuB site formation of cytochrome c oxidase., Banci L, Bertini I, Cantini F, Ciofi-Baffoni S, Gonnelli L, Mangani S, J Biol Chem. 2004 Aug 13;279(33):34833-9. Epub 2004 Jun 4. PMID:15181013

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