8zuj: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
m Protected "8zuj" [edit=sysop:move=sysop]
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
Line 1: Line 1:
'''Unreleased structure'''


The entry 8zuj is ON HOLD
==Pentagonal cluster of BAFF-BAFFR ectodomain complex==
 
<StructureSection load='8zuj' size='340' side='right'caption='[[8zuj]], [[Resolution|resolution]] 2.58&Aring;' scene=''>
Authors: Lim, C.S., Lee, J.O.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8zuj]] is a 30 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ZUJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ZUJ FirstGlance]. <br>
Description: Pentagonal cluster of BAFF-BAFFR ectodomain complex
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.58&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8zuj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8zuj OCA], [https://pdbe.org/8zuj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8zuj RCSB], [https://www.ebi.ac.uk/pdbsum/8zuj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8zuj ProSAT]</span></td></tr>
[[Category: Lee, J.O]]
</table>
[[Category: Lim, C.S]]
== Disease ==
[https://www.uniprot.org/uniprot/TR13C_HUMAN TR13C_HUMAN] Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:[https://omim.org/entry/613494 613494]; also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.<ref>PMID:19666484</ref>
== Function ==
[https://www.uniprot.org/uniprot/TR13C_HUMAN TR13C_HUMAN] B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.<ref>PMID:11591325</ref> <ref>PMID:12387744</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Lee JO]]
[[Category: Lim CS]]
Retrieved from "https://proteopedia.org/8zuj"