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[[Image:1spr.gif|left|200px]]
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[[Image:1spr.png|left|200px]]


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{{STRUCTURE_1spr|  PDB=1spr  |  SCENE=  }}  
{{STRUCTURE_1spr|  PDB=1spr  |  SCENE=  }}  


'''BINDING OF A HIGH AFFINITY PHOSPHOTYROSYL PEPTIDE TO THE SRC SH2 DOMAIN: CRYSTAL STRUCTURES OF THE COMPLEXED AND PEPTIDE-FREE FORMS'''
===BINDING OF A HIGH AFFINITY PHOSPHOTYROSYL PEPTIDE TO THE SRC SH2 DOMAIN: CRYSTAL STRUCTURES OF THE COMPLEXED AND PEPTIDE-FREE FORMS===




==Overview==
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The crystal structure of the Src SH2 domain complexed with a high affinity 11-residue phosphopeptide has been determined at 2.7 A resolution by X-ray diffraction. The peptide binds in an extended conformation and makes primary interactions with the SH2 domain at six central residues: PQ(pY)EEI. The phosphotyrosine and the isoleucine are tightly bound by two well-defined pockets on the protein surface, resulting in a complex that resembles a two-pronged plug engaging a two-holed socket. The glutamate residues are in solvent-exposed environments in the vicinity of basic side chains of the SH2 domain, and the two N-terminal residues cap the phosphotyrosine-binding site. The crystal structure of Src SH2 in the absence of peptide has been determined at 2.5 A resolution, and comparison with the structure of the high affinity complex reveals only localized and relatively small changes.
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{{ABSTRACT_PUBMED_7680960}}


==About this Structure==
==About this Structure==
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[[Category: Kuriyan, J.]]
[[Category: Kuriyan, J.]]
[[Category: Waksman, G.]]
[[Category: Waksman, G.]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:59:30 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:26:31 2008''

Revision as of 03:26, 29 July 2008

File:1spr.png

Template:STRUCTURE 1spr

BINDING OF A HIGH AFFINITY PHOSPHOTYROSYL PEPTIDE TO THE SRC SH2 DOMAIN: CRYSTAL STRUCTURES OF THE COMPLEXED AND PEPTIDE-FREE FORMS

Template:ABSTRACT PUBMED 7680960

About this Structure

1SPR is a Single protein structure of sequence from Rous sarcoma virus. Full crystallographic information is available from OCA.

Reference

Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms., Waksman G, Shoelson SE, Pant N, Cowburn D, Kuriyan J, Cell. 1993 Mar 12;72(5):779-90. PMID:7680960

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