1sr3: Difference between revisions

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[[Image:1sr3.~~gif~~|left|200px]]

[[Image:1sr3.png|left|200px]]

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~~'''~~Solution structure of the heme chaperone CcmE of Escherichia coli~~'''~~

===Solution structure of the heme chaperone CcmE of Escherichia coli===

~~==Overview==~~

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The ~~concept of metal chaperones involves transient binding of metallic cofactors by specific proteins for delivery to enzymes in which they function. Metal chaperones thus provide a protective~~, ~~as well as a transport~~, ~~function. We report~~ the ~~first structure of a heme chaperone, CcmE, which comprises these two functions. We propose that~~ the ~~covalent attachment of heme to an exposed histidine occurs after heme binding~~ at ~~the surface of a rigid molecule with a flexible C-terminal domain~~. ~~CcmE belongs to a family of proteins with a specific fold~~, ~~which all share a function in delivery of specific molecular cargo~~.

The line below this paragraph, {{ABSTRACT_PUBMED_12429096}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12429096 is the PubMed ID number.

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==About this Structure==

1SR3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1liz 1liz]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SR3 OCA].

1SR3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1liz 1liz]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SR3 OCA].

==Reference==

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[[Category: Flexible c-terminal domain]]

[[Category: Ob fold]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 09~~:02:56 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:05:38 2008''

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-[[Image:1sr3.gif|left|200px]]
+{{Seed}}
+[[Image:1sr3.png|left|200px]]
 <!--
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 {{STRUCTURE_1sr3|  PDB=1sr3  |  SCENE=  }}
-'''Solution structure of the heme chaperone CcmE of Escherichia coli'''
+===Solution structure of the heme chaperone CcmE of Escherichia coli===
-==Overview==
+<!--
-The concept of metal chaperones involves transient binding of metallic cofactors by specific proteins for delivery to enzymes in which they function. Metal chaperones thus provide a protective, as well as a transport, function. We report the first structure of a heme chaperone, CcmE, which comprises these two functions. We propose that the covalent attachment of heme to an exposed histidine occurs after heme binding at the surface of a rigid molecule with a flexible C-terminal domain. CcmE belongs to a family of proteins with a specific fold, which all share a function in delivery of specific molecular cargo.
+The line below this paragraph, {{ABSTRACT_PUBMED_12429096}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12429096 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12429096}}
 ==About this Structure==
-SR3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1liz 1liz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SR3 OCA].
+SR3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1liz 1liz]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SR3 OCA].
 ==Reference==
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 [[Category: Flexible c-terminal domain]]
 [[Category: Ob fold]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 09:02:56 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:05:38 2008''