Histone: Difference between revisions

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The nucleosome core is formed of two <scene name='46/468228/H2a_h2b_dimer/1'>H2A-H2B dimers</scene> and a <scene name='46/468228/H4_h3_tetramer/1'>H3-H4 tetramer</scene>, forming two nearly <scene name='46/468228/Nucleosome_dimer/1'>symmetrical halves</scene> by tertiary structure.<ref name=pmid9305837/> 147 base pairs of <scene name='46/468228/Dna_wrap_around_histone/1'>DNA wrap</scene> around this core particle 1.65 times in a left-handed super-helical turn.<ref name=pmid9305837>PMID: 9305837</ref> The linker histone H1 binds the nucleosome and the entry and exit sites of the DNA, thus locking the DNA into place<ref name="isbn0-915274-84-1">{{cite book |author=Farkas, Daniel |title=DNA simplified: the hitchhiker's guide to DNA |publisher=AACC Press |location=Washington, D.C |year=1996 |isbn=0-915274-84-1 }}</ref> and allowing the formation of higher order structure.

The '''nucleosome''' core is formed of two <scene name='46/468228/H2a_h2b_dimer/1'>H2A-H2B dimers</scene> and a <scene name='46/468228/H4_h3_tetramer/1'>H3-H4 tetramer</scene>, forming two nearly <scene name='46/468228/Nucleosome_dimer/1'>symmetrical halves</scene> by tertiary structure.<ref name=pmid9305837/> 147 base pairs of <scene name='46/468228/Dna_wrap_around_histone/1'>DNA wrap</scene> around this core particle 1.65 times in a left-handed super-helical turn.<ref name=pmid9305837>PMID: 9305837</ref> The linker histone H1 binds the nucleosome and the entry and exit sites of the DNA, thus locking the DNA into place<ref name="isbn0-915274-84-1">{{cite book |author=Farkas, Daniel |title=DNA simplified: the hitchhiker's guide to DNA |publisher=AACC Press |location=Washington, D.C |year=1996 |isbn=0-915274-84-1 }}</ref> and allowing the formation of higher order structure.

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Revision as of 07:36, 2 July 2024 view source Michal Harel (talk \| contribs) 32,826 edits No edit summary ← Older edit		Revision as of 07:40, 2 July 2024 view source Michal Harel (talk \| contribs) 32,826 edits No edit summary Newer edit →
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	The nucleosome core is formed of two <scene name='46/468228/H2a_h2b_dimer/1'>H2A-H2B dimers</scene> and a <scene name='46/468228/H4_h3_tetramer/1'>H3-H4 tetramer</scene>, forming two nearly <scene name='46/468228/Nucleosome_dimer/1'>symmetrical halves</scene> by tertiary structure.<ref name=pmid9305837/> 147 base pairs of <scene name='46/468228/Dna_wrap_around_histone/1'>DNA wrap</scene> around this core particle 1.65 times in a left-handed super-helical turn.<ref name=pmid9305837>PMID: 9305837</ref> The linker histone H1 binds the nucleosome and the entry and exit sites of the DNA, thus locking the DNA into place<ref name="isbn0-915274-84-1">{{cite book \|author=Farkas, Daniel \|title=DNA simplified: the hitchhiker's guide to DNA \|publisher=AACC Press \|location=Washington, D.C \|year=1996 \|isbn=0-915274-84-1 }}</ref> and allowing the formation of higher order structure.		The '''nucleosome''' core is formed of two <scene name='46/468228/H2a_h2b_dimer/1'>H2A-H2B dimers</scene> and a <scene name='46/468228/H4_h3_tetramer/1'>H3-H4 tetramer</scene>, forming two nearly <scene name='46/468228/Nucleosome_dimer/1'>symmetrical halves</scene> by tertiary structure.<ref name=pmid9305837/> 147 base pairs of <scene name='46/468228/Dna_wrap_around_histone/1'>DNA wrap</scene> around this core particle 1.65 times in a left-handed super-helical turn.<ref name=pmid9305837>PMID: 9305837</ref> The linker histone H1 binds the nucleosome and the entry and exit sites of the DNA, thus locking the DNA into place<ref name="isbn0-915274-84-1">{{cite book \|author=Farkas, Daniel \|title=DNA simplified: the hitchhiker's guide to DNA \|publisher=AACC Press \|location=Washington, D.C \|year=1996 \|isbn=0-915274-84-1 }}</ref> and allowing the formation of higher order structure.