9ij9: Difference between revisions
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==A Cryo-EM structure of Bitter taste receptor TAS2R14 with Gi complex== | |||
<StructureSection load='9ij9' size='340' side='right'caption='[[9ij9]], [[Resolution|resolution]] 2.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9ij9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9IJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9IJ9 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.7Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1AEI:4-methyl-N-[(2M)-2-(1H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine'>A1AEI</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ij9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ij9 OCA], [https://pdbe.org/9ij9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ij9 RCSB], [https://www.ebi.ac.uk/pdbsum/9ij9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ij9 ProSAT]</span></td></tr> | ||
[[Category: Tao | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Duan J]] | |||
[[Category: Tao L]] | |||
[[Category: Xu EH]] | |||
[[Category: Yuan Q]] | |||
Latest revision as of 06:38, 24 July 2024
A Cryo-EM structure of Bitter taste receptor TAS2R14 with Gi complex
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