1sv4: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,484 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,484 edits
No edit summary
Line 1: Line 1:
[[Image:1sv4.jpg|left|200px]]
{{Seed}}
[[Image:1sv4.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1sv4|  PDB=1sv4  |  SCENE=  }}  
{{STRUCTURE_1sv4|  PDB=1sv4  |  SCENE=  }}  


'''Crystal Structure of Yan-SAM'''
===Crystal Structure of Yan-SAM===




==Overview==
<!--
Yan, an ETS family transcriptional repressor, is regulated by receptor tyrosine kinase signaling via the Ras/MAPK pathway. Phosphorylation and downregulation of Yan is facilitated by a protein called Mae. Yan and Mae interact through their SAM domains. We find that repression by Yan requires the formation of a higher order structure mediated by Yan-SAM polymerization. Moreover, a crystal structure of the Yan-SAM/Mae-SAM complex shows that Mae-SAM specifically recognizes a surface on Yan-SAM that is also required for Yan-SAM polymerization. Mae-SAM binds to Yan-SAM with approximately 1000-fold higher affinity than Yan-SAM binds to itself and can effectively depolymerize Yan-SAM. Mutations on Mae that specifically disrupt its SAM domain-dependent interactions with Yan disable the derepression function of Mae in vivo. Depolymerization of Yan by Mae represents a novel mechanism of transcriptional control that sensitizes Yan for regulation by receptor tyrosine kinases.
The line below this paragraph, {{ABSTRACT_PUBMED_15260987}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15260987 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_15260987}}


==About this Structure==
==About this Structure==
Line 32: Line 36:
[[Category: Song, H.]]
[[Category: Song, H.]]
[[Category: Alpha-helix]]
[[Category: Alpha-helix]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 09:10:12 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:29:10 2008''
Retrieved from "https://proteopedia.org/1sv4"