1svf: Difference between revisions

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[[Image:1svf.jpg|left|200px]]
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[[Image:1svf.png|left|200px]]


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{{STRUCTURE_1svf|  PDB=1svf  |  SCENE=  }}  
{{STRUCTURE_1svf|  PDB=1svf  |  SCENE=  }}  


'''PARAMYXOVIRUS SV5 FUSION PROTEIN CORE'''
===PARAMYXOVIRUS SV5 FUSION PROTEIN CORE===




==Overview==
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Paramyxoviruses are responsible for significant human mortality and disease worldwide, but the molecular mechanisms underlying their entry into host cells remain poorly understood. We have solved the crystal structure of a fragment of the simian parainfluenza virus 5 fusion protein (SV5 F), revealing a 96 A long coiled coil surrounded by three antiparallel helices. This structure places the fusion and transmembrane anchor of SV5 F in close proximity with a large intervening domain at the opposite end of the coiled coil. Six amino acids, potentially part of the fusion peptide, form a segment of the central coiled coil, suggesting that this structure extends into the membrane. Deletion mutants of SV5 F indicate that putative flexible tethers between the coiled coil and the viral membrane are dispensable for fusion. The lack of flexible tethers may couple a final conformational change in the F protein directly to the fusion of two bilayers.
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{{ABSTRACT_PUBMED_10198633}}


==About this Structure==
==About this Structure==
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[[Category: Paramyxovirus]]
[[Category: Paramyxovirus]]
[[Category: Sv5]]
[[Category: Sv5]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 09:10:45 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:11:08 2008''

Revision as of 18:11, 28 July 2008

File:1svf.png

Template:STRUCTURE 1svf

PARAMYXOVIRUS SV5 FUSION PROTEIN CORE

Template:ABSTRACT PUBMED 10198633

About this Structure

1SVF is a Protein complex structure of sequences from Simian virus 5. Full crystallographic information is available from OCA.

Reference

Structural basis for paramyxovirus-mediated membrane fusion., Baker KA, Dutch RE, Lamb RA, Jardetzky TS, Mol Cell. 1999 Mar;3(3):309-19. PMID:10198633

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