9ijr: Difference between revisions
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==Cryo-EM structure of the orphan GPR52 beta-arrestin 1 complex bound to ligand c17== | |||
<StructureSection load='9ijr' size='340' side='right'caption='[[9ijr]], [[Resolution|resolution]] 3.86Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9ijr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9IJR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9IJR FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.86Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EN6:~{N}-(2-hydroxyethyl)-5-(hydroxymethyl)-3-methyl-1-[2-[[3-(trifluoromethyl)phenyl]methyl]-1-benzothiophen-7-yl]pyrazole-4-carboxamide'>EN6</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ijr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ijr OCA], [https://pdbe.org/9ijr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ijr RCSB], [https://www.ebi.ac.uk/pdbsum/9ijr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ijr ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GPR52_HUMAN GPR52_HUMAN] Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (PubMed:24587241). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241). Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228).<ref>PMID:24587241</ref> <ref>PMID:25738228</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Lin X]] | |||
[[Category: Xu F]] | |||
Latest revision as of 10:28, 3 September 2025
Cryo-EM structure of the orphan GPR52 beta-arrestin 1 complex bound to ligand c17
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