1svz: Difference between revisions

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[[Image:1svz.gif|left|200px]]
{{Seed}}
[[Image:1svz.png|left|200px]]


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{{STRUCTURE_1svz|  PDB=1svz  |  SCENE=  }}  
{{STRUCTURE_1svz|  PDB=1svz  |  SCENE=  }}  


'''Crystal structure of the single-chain Fv fragment 1696 in complex with the epitope peptide corresponding to N-terminus of HIV-2 protease'''
===Crystal structure of the single-chain Fv fragment 1696 in complex with the epitope peptide corresponding to N-terminus of HIV-2 protease===




==Overview==
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The monoclonal antibody 1696, elicited by HIV-1 protease, inhibits the activity of both HIV-1 and HIV-2 proteases with inhibition constants in the low nanomolar range. The antibody cross-reacts with peptides derived from the N-terminal region of both proteases. The crystal structure of the recombinant single-chain Fv fragment of 1696 complexed with an N-terminal peptide from the HIV-2 protease has been determined at 1.88A resolution. Interactions of the peptide with scFv1696 are compared with the previously reported structure of scFv1696 in complex with the corresponding peptide from HIV-1 protease. The origin of cross-reactivity of mAb1696 with HIV proteases is discussed.
The line below this paragraph, {{ABSTRACT_PUBMED_15721587}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15721587 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15721587}}


==About this Structure==
==About this Structure==
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[[Category: Antibody-antigen complex]]
[[Category: Antibody-antigen complex]]
[[Category: Hiv inhibiting antibody]]
[[Category: Hiv inhibiting antibody]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 09:12:06 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:50:21 2008''
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