ConSurfDB vs. ConSurf: Difference between revisions
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====ConSurfDB==== | ====ConSurfDB==== | ||
ConSurfDB has a result (NOT SHOWN) with an '''APD of 1.63'''. Conservation of important residues in the groove is obscured by inclusion in the MSA of proteins with different functions ([[# see above]]. The sides of the groove are variable, as expected (enabling it to bind a wide range of peptide sequences). The only groove residue that is conserved at greater than level 6 is Leu5 (level 8), part of a hydrophobic pocket that binds a peptide "anchor residue". Only a handful of surface residues are highly conserved (level 8), including Trp274 involved in binding CD8. | ConSurfDB has a result (NOT SHOWN) with an '''APD of 1.63'''. Conservation of important residues in the groove is obscured by inclusion in the MSA of proteins with different functions ([[#See such examples|see analysis above]]. The sides of the groove are variable, as expected (enabling it to bind a wide range of peptide sequences). The only groove residue that is conserved at greater than level 6 is Leu5 (level 8), part of a hydrophobic pocket that binds a peptide "anchor residue". Only a handful of surface residues are highly conserved (level 8), including Trp274 involved in binding CD8. | ||
