9coj: Difference between revisions

Latest revision as of 06:09, 31 July 2024

SH3-like tandem domain of human KIN protein

Structural highlights

9coj is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KIN17_HUMAN Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro.[UniProtKB:Q8K339]^[1] ^[2] ^[3] ^[4] ^[5] ^[6]

References

↑ Biard DS, Miccoli L, Despras E, Frobert Y, Creminon C, Angulo JF. Ionizing radiation triggers chromatin-bound kin17 complex formation in human cells. J Biol Chem. 2002 May 24;277(21):19156-65. PMID:11880372 doi:10.1074/jbc.M200321200
↑ Miccoli L, Biard DS, Créminon C, Angulo JF. Human kin17 protein directly interacts with the simian virus 40 large T antigen and inhibits DNA replication. Cancer Res. 2002 Oct 1;62(19):5425-35 PMID:12359749
↑ Biard DS, Miccoli L, Despras E, Harper F, Pichard E, Créminon C, Angulo JF. Participation of kin17 protein in replication factories and in other DNA transactions mediated by high molecular weight nuclear complexes. Mol Cancer Res. 2003 May;1(7):519-31 PMID:12754299
↑ Miccoli L, Biard DS, Frouin I, Harper F, Maga G, Angulo JF. Selective interactions of human kin17 and RPA proteins with chromatin and the Nucleic Acids Res. 2003 Jul 15;31(14):4162-75. PMID:12853634 doi:10.1093/nar/gkg459
↑ Miccoli L, Frouin I, Novac O, Di Paola D, Harper F, Zannis-Hadjopoulos M, Maga G, Biard DS, Angulo JF. The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins. Mol Cell Biol. 2005 May;25(9):3814-30. PMID:15831485 doi:10.1128/MCB.25.9.3814-3830.2005
↑ le Maire A, Schiltz M, Stura EA, Pinon-Lataillade G, Couprie J, Moutiez M, Gondry M, Angulo JF, Zinn-Justin S. A tandem of SH3-like domains participates in RNA binding in KIN17, a human protein activated in response to genotoxics. J Mol Biol. 2006 Dec 8;364(4):764-76. Epub 2006 Sep 16. PMID:17045609 doi:10.1016/j.jmb.2006.09.033

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OCA

[1] Biard DS, Miccoli L, Despras E, Frobert Y, Creminon C, Angulo JF. Ionizing radiation triggers chromatin-bound kin17 complex formation in human cells. J Biol Chem. 2002 May 24;277(21):19156-65. PMID:11880372 doi:10.1074/jbc.M200321200

[2] Miccoli L, Biard DS, Créminon C, Angulo JF. Human kin17 protein directly interacts with the simian virus 40 large T antigen and inhibits DNA replication. Cancer Res. 2002 Oct 1;62(19):5425-35 PMID:12359749

[3] Biard DS, Miccoli L, Despras E, Harper F, Pichard E, Créminon C, Angulo JF. Participation of kin17 protein in replication factories and in other DNA transactions mediated by high molecular weight nuclear complexes. Mol Cancer Res. 2003 May;1(7):519-31 PMID:12754299

[4] Miccoli L, Biard DS, Frouin I, Harper F, Maga G, Angulo JF. Selective interactions of human kin17 and RPA proteins with chromatin and the Nucleic Acids Res. 2003 Jul 15;31(14):4162-75. PMID:12853634 doi:10.1093/nar/gkg459

[5] Miccoli L, Frouin I, Novac O, Di Paola D, Harper F, Zannis-Hadjopoulos M, Maga G, Biard DS, Angulo JF. The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins. Mol Cell Biol. 2005 May;25(9):3814-30. PMID:15831485 doi:10.1128/MCB.25.9.3814-3830.2005

[6] Maire A, Schiltz M, Stura EA, Pinon-Lataillade G, Couprie J, Moutiez M, Gondry M, Angulo JF, Zinn-Justin S. A tandem of SH3-like domains participates in RNA binding in KIN17, a human protein activated in response to genotoxics. J Mol Biol. 2006 Dec 8;364(4):764-76. Epub 2006 Sep 16. PMID:17045609 doi:10.1016/j.jmb.2006.09.033

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9coj is ON HOLD
+==SH3-like tandem domain of human KIN protein==
+<StructureSection load='9coj' size='340' side='right'caption='[[9coj]]' scene=''>
-Authors: de Lourenco, I.O., Fossey, M.A., Souza, F.P., Seixas, F.A.V., Fernandez, M.A., Almeida, F.C.L., Caruso, I.P.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9coj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9COJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9COJ FirstGlance]. <br>
-Description: SH3-like tandem domain of human KIN protein
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9coj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9coj OCA], [https://pdbe.org/9coj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9coj RCSB], [https://www.ebi.ac.uk/pdbsum/9coj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9coj ProSAT]</span></td></tr>
-[[Category: Fernandez, M.A]]
+</table>
-[[Category: Souza, F.P]]
+== Function ==
-[[Category: Almeida, F.C.L]]
+[https://www.uniprot.org/uniprot/KIN17_HUMAN KIN17_HUMAN] Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro.[UniProtKB:Q8K339]<ref>PMID:11880372</ref> <ref>PMID:12359749</ref> <ref>PMID:12754299</ref> <ref>PMID:12853634</ref> <ref>PMID:15831485</ref> <ref>PMID:17045609</ref>
-[[Category: Fossey, M.A]]
+== References ==
-[[Category: De Lourenco, I.O]]
+<references/>
-[[Category: Seixas, F.A.V]]
+__TOC__
-[[Category: Caruso, I.P]]
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Almeida FCL]]
+[[Category: Caruso IP]]
+[[Category: Fernandez MA]]
+[[Category: Fossey MA]]
+[[Category: Seixas FAV]]
+[[Category: Souza FP]]
+[[Category: De Lourenco IO]]

9coj: Difference between revisions

Latest revision as of 06:09, 31 July 2024

SH3-like tandem domain of human KIN protein

Structural highlights

Function

References

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