ConSurfDB vs. ConSurf: Difference between revisions

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Evolutionary Conservation is introduced at [[Introduction to Evolutionary Conservation]], and treated in somewhat greater depth in the article [[Conservation, Evolutionary]]. These describe how conservation patterns in 3D can help to identify functional sites in proteins. Proteopedia displays conservation patterns pre-calculated by [http://consurfdb.tau.ac.il ConSurfDB], when available. These are usually based on broad protein families that include sequences of proteins with multiple functions. Consequently, they usually '''obscure conservation''' present in a family of proteins with a single function (see [[Conservation%2C_Evolutionary#Caveats|Caveats]]). The present article explains '''how to use options available at the ConSurf Server to reveal conservation within a group limited to proteins with a single function'''. Several [[#Examples|examples are presented]]. The mechanisms utilized by ConSurfDB and ConSurf Servers are also summarized.

Evolutionary Conservation is introduced at [[Introduction to Evolutionary Conservation]], and treated in somewhat greater depth in the article [[Conservation, Evolutionary]]. These describe how conservation patterns in 3D can help to identify functional sites in proteins. Proteopedia displays conservation patterns pre-calculated by [http://consurfdb.tau.ac.il ConSurfDB], when available. These are usually based on broad protein families that include sequences of proteins with multiple functions. Consequently, they usually '''obscure conservation''' present in a family of proteins with a single function (see [[Conservation%2C_Evolutionary#Caveats|Caveats]]).

The present article explains '''how to use options available at the ConSurf Server to reveal conservation within a group limited to proteins with a single function'''. Several [[#Examples|examples are presented]]. The mechanisms utilized by ConSurfDB and ConSurf Servers are also summarized.

==The Two ConSurf Servers==

ConSurfDB vs. ConSurf: Difference between revisions

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-Evolutionary Conservation is introduced at [[Introduction to Evolutionary Conservation]], and treated in somewhat greater depth in the article [[Conservation, Evolutionary]]. These describe how conservation patterns in 3D can help to identify functional sites in proteins. Proteopedia displays conservation patterns pre-calculated by [http://consurfdb.tau.ac.il ConSurfDB], when available. These are usually based on broad protein families that include sequences of proteins with multiple functions. Consequently, they usually '''obscure conservation''' present in a family of proteins with a single function (see [[Conservation%2C_Evolutionary#Caveats|Caveats]]). The present article explains '''how to use options available at the ConSurf Server to reveal conservation within a group limited to proteins with a single function'''. Several [[#Examples|examples are presented]]. The mechanisms utilized by ConSurfDB and ConSurf Servers are also summarized.
+Evolutionary Conservation is introduced at [[Introduction to Evolutionary Conservation]], and treated in somewhat greater depth in the article [[Conservation, Evolutionary]]. These describe how conservation patterns in 3D can help to identify functional sites in proteins. Proteopedia displays conservation patterns pre-calculated by [http://consurfdb.tau.ac.il ConSurfDB], when available. These are usually based on broad protein families that include sequences of proteins with multiple functions. Consequently, they usually '''obscure conservation''' present in a family of proteins with a single function (see [[Conservation%2C_Evolutionary#Caveats|Caveats]]).
+The present article explains '''how to use options available at the ConSurf Server to reveal conservation within a group limited to proteins with a single function'''. Several [[#Examples|examples are presented]]. The mechanisms utilized by ConSurfDB and ConSurf Servers are also summarized.
 ==The Two ConSurf Servers==