ConSurfDB vs. ConSurf: Difference between revisions
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With the default ConSurf Server result (APD 1.42), salt bridged residues are less conserved than average. With a custom ConSurf Server result APD 0.91, the salt-bridged residues rise to average conservation. With a custom result APD 0.48, the between-chain salt bridges have above-average conservation (7.6 vs. 6.2), while the within-chain salt bridges have average conservation (6.3). In conclusion, when the multiple sequence alignment is limited to sequences closely related to the query (APD 0.48), '''between-chain salt bridged residues are more conserved than are within-chain salt bridged residues.''' | With the default ConSurf Server result (APD 1.42), salt bridged residues are less conserved than average. With a custom ConSurf Server result APD 0.91, the salt-bridged residues rise to average conservation. With a custom result APD 0.48, the between-chain salt bridges have above-average conservation (7.6 vs. 6.2), while the within-chain salt bridges have average conservation (6.3). In conclusion, when the multiple sequence alignment is limited to sequences closely related to the query (APD 0.48), '''between-chain salt bridged residues are more conserved than are within-chain salt bridged residues.''' | ||
<table class="wikitable"> | <table class="wikitable" align="center"> | ||
<tr> | <tr> | ||
<td colspan=5> | |||
Salt Bridges in [[4dnw]] | |||
</td> | |||
</tr><tr> | |||
<td rowspan=2> | <td rowspan=2> | ||
[[#Average Pairwise Distance|APD]] | [[#Average Pairwise Distance|APD]] | ||
