ConSurfDB vs. ConSurf: Difference between revisions
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[[Image:2vaa-APD0.31-40degslow.gif]] | |||
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Conservation of amino acids non-covalently interacting with a peptide in the groove of [https://www.youtube.com/watch?v=2ZakngfbHSo Major Histocompatibility Protein] Class I ([[2vaa]]). Conservation was not revealed until an [[#Average Pairwise Distance]] of 0.31 was achieved in a customized ConSurf Server job. | |||
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Evolutionary Conservation is introduced at [[Introduction to Evolutionary Conservation]], and treated in somewhat greater depth in the article [[Conservation, Evolutionary]]. These describe how conservation patterns in 3D can help to identify functional sites in proteins. Proteopedia displays conservation patterns pre-calculated by [http://consurfdb.tau.ac.il ConSurfDB], when available. These are usually based on broad protein families that include sequences of proteins with multiple functions. Consequently, they usually '''obscure conservation''' present in a family of proteins with a single function (see [[Conservation%2C_Evolutionary#Caveats|Caveats]]). | Evolutionary Conservation is introduced at [[Introduction to Evolutionary Conservation]], and treated in somewhat greater depth in the article [[Conservation, Evolutionary]]. These describe how conservation patterns in 3D can help to identify functional sites in proteins. Proteopedia displays conservation patterns pre-calculated by [http://consurfdb.tau.ac.il ConSurfDB], when available. These are usually based on broad protein families that include sequences of proteins with multiple functions. Consequently, they usually '''obscure conservation''' present in a family of proteins with a single function (see [[Conservation%2C_Evolutionary#Caveats|Caveats]]). | ||
