9c87: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry 9c87 is ON HOLD until Paper Publication~~

==Cryo-EM Structure of a Proteolytic ClpXP AAA+ Machine Poised to Unfold a Linear-Degron DHFR-ssrA Substrate Bound with MTX==

~~Authors: Ghanbarpour, A., Sauer, R.T., Davis, J.H.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[9c87]] is a 21 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9C87 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9C87 FirstGlance].

~~Description:~~ Cryo-EM Structure of a Proteolytic ClpXP AAA+ Machine Poised to Unfold a Linear-Degron DHFR-ssrA Substrate Bound with MTX

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene></td></tr>

[[Category: Davis~~, J.H~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9c87 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9c87 OCA], [https://pdbe.org/9c87 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9c87 RCSB], [https://www.ebi.ac.uk/pdbsum/9c87 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9c87 ProSAT]</td></tr>

[[Category: Ghanbarpour, A]]

</table>

[[Category: Sauer~~, R.T~~]]

== Function ==

[https://www.uniprot.org/uniprot/CLPX_ECOLI CLPX_ECOLI] ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. It may bind to the lambda O substrate protein and present it to the ClpP protease in a form that can be recognized and readily hydrolyzed by ClpP. Can perform chaperone functions in the absence of ClpP.[HAMAP-Rule:MF_00175]

__TOC__

</StructureSection>

[[Category: Escherichia coli]]

[[Category: Large Structures]]

[[Category: Davis JH]]

[[Category: Ghanbarpour A]]

[[Category: Sauer RT]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9c87 is ON HOLD  until Paper Publication
+==Cryo-EM Structure of a Proteolytic ClpXP AAA+ Machine Poised to Unfold a Linear-Degron DHFR-ssrA Substrate Bound with MTX==
+<StructureSection load='9c87' size='340' side='right'caption='[[9c87]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
-Authors: Ghanbarpour, A., Sauer, R.T., Davis, J.H.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9c87]] is a 21 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9C87 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9C87 FirstGlance]. <br>
-Description: Cryo-EM Structure of a Proteolytic ClpXP AAA+ Machine Poised to Unfold a Linear-Degron DHFR-ssrA Substrate Bound with MTX
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene></td></tr>
-[[Category: Davis, J.H]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9c87 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9c87 OCA], [https://pdbe.org/9c87 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9c87 RCSB], [https://www.ebi.ac.uk/pdbsum/9c87 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9c87 ProSAT]</span></td></tr>
-[[Category: Ghanbarpour, A]]
+</table>
-[[Category: Sauer, R.T]]
+== Function ==
+[https://www.uniprot.org/uniprot/CLPX_ECOLI CLPX_ECOLI] ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. It may bind to the lambda O substrate protein and present it to the ClpP protease in a form that can be recognized and readily hydrolyzed by ClpP. Can perform chaperone functions in the absence of ClpP.[HAMAP-Rule:MF_00175]
+__TOC__
+</StructureSection>
+[[Category: Escherichia coli]]
+[[Category: Large Structures]]
+[[Category: Davis JH]]
+[[Category: Ghanbarpour A]]
+[[Category: Sauer RT]]