1t0p: Difference between revisions

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[[Image:1t0p.~~gif~~|left|200px]]

[[Image:1t0p.png|left|200px]]

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~~'''~~Structural Basis of ICAM recognition by integrin alpahLbeta2 revealed in the complex structure of binding domains of ICAM-3 and alphaLbeta2 at 1.65 A~~'''~~

===Structural Basis of ICAM recognition by integrin alpahLbeta2 revealed in the complex structure of binding domains of ICAM-3 and alphaLbeta2 at 1.65 A===

~~==Overview==~~

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~~Within~~ the ~~Ig superfamily~~ (~~IgSF), intercellular adhesion molecules (ICAMs) form a subfamily that binds the leukocyte integrin alphaLbeta2~~. ~~We report a 1~~.~~65-A-resolution crystal structure of the ICAM-3 N-terminal domain (D1~~) ~~in complex with the inserted domain~~, the ~~ligand-binding domain of alphaLbeta2~~. ~~This high~~-~~resolution structure and comparisons among ICAM subfamily members establish that the binding of ICAM~~-3 D1 onto the inserted domain represents a common docking mode for ICAM subfamily members. The markedly different off-rates of ICAM-1, -2, and -3 appear to be determined by the hydrophobicity of residues that surround a metal coordination bond in the alphaLbeta2-binding interfaces. Variation in composition of glycans on the periphery of the interfaces influences on-rate.

The line below this paragraph, {{ABSTRACT_PUBMED_15728350}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 15728350 is the PubMed ID number.

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==About this Structure==

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[[Category: Ig-super family domain]]

[[Category: Rossmann fold]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 09~~:21:41 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:27:41 2008''

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-[[Image:1t0p.gif|left|200px]]
+{{Seed}}
+[[Image:1t0p.png|left|200px]]
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 {{STRUCTURE_1t0p|  PDB=1t0p  |  SCENE=  }}
-'''Structural Basis of ICAM recognition by integrin alpahLbeta2 revealed in the complex structure of binding domains of ICAM-3 and alphaLbeta2 at 1.65 A'''
+===Structural Basis of ICAM recognition by integrin alpahLbeta2 revealed in the complex structure of binding domains of ICAM-3 and alphaLbeta2 at 1.65 A===
-==Overview==
+<!--
-Within the Ig superfamily (IgSF), intercellular adhesion molecules (ICAMs) form a subfamily that binds the leukocyte integrin alphaLbeta2. We report a 1.65-A-resolution crystal structure of the ICAM-3 N-terminal domain (D1) in complex with the inserted domain, the ligand-binding domain of alphaLbeta2. This high-resolution structure and comparisons among ICAM subfamily members establish that the binding of ICAM-3 D1 onto the inserted domain represents a common docking mode for ICAM subfamily members. The markedly different off-rates of ICAM-1, -2, and -3 appear to be determined by the hydrophobicity of residues that surround a metal coordination bond in the alphaLbeta2-binding interfaces. Variation in composition of glycans on the periphery of the interfaces influences on-rate.
+The line below this paragraph, {{ABSTRACT_PUBMED_15728350}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15728350 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15728350}}
 ==About this Structure==
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 [[Category: Ig-super family domain]]
 [[Category: Rossmann fold]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 09:21:41 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:27:41 2008''