9cyp: Difference between revisions

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'''Unreleased structure'''


The entry 9cyp is ON HOLD
==Crystal structure of I19V mutant human PTP1B (PTPN1) at room temperature (298 K)==
 
<StructureSection load='9cyp' size='340' side='right'caption='[[9cyp]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
Authors: Ebrahim, A., Perdikari, A., Woods, V.A., Lawler, K., Bounds, R., Singh, N.I., Mehlman, T., Riley, B.T., Sharma, S., Morris, J.W., Keogh, J.M., Henning, E., Smith, M., Farooqi, I.S., Keedy, D.A.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9cyp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9CYP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9CYP FirstGlance]. <br>
Description: Crystal structure of I19V mutant human PTP1B (PTPN1) at room temperature (298 K)
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9cyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9cyp OCA], [https://pdbe.org/9cyp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9cyp RCSB], [https://www.ebi.ac.uk/pdbsum/9cyp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9cyp ProSAT]</span></td></tr>
[[Category: Riley, B.T]]
</table>
[[Category: Keogh, J.M]]
== Function ==
[[Category: Singh, N.I]]
[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
[[Category: Farooqi, I.S]]
== References ==
[[Category: Bounds, R]]
<references/>
[[Category: Lawler, K]]
__TOC__
[[Category: Henning, E]]
</StructureSection>
[[Category: Ebrahim, A]]
[[Category: Homo sapiens]]
[[Category: Sharma, S]]
[[Category: Large Structures]]
[[Category: Morris, J.W]]
[[Category: Bounds R]]
[[Category: Perdikari, A]]
[[Category: Ebrahim A]]
[[Category: Keedy, D.A]]
[[Category: Farooqi IS]]
[[Category: Smith, M]]
[[Category: Henning E]]
[[Category: Woods, V.A]]
[[Category: Keedy DA]]
[[Category: Mehlman, T]]
[[Category: Keogh JM]]
[[Category: Lawler K]]
[[Category: Mehlman T]]
[[Category: Morris JW]]
[[Category: Perdikari A]]
[[Category: Riley BT]]
[[Category: Sharma S]]
[[Category: Singh NI]]
[[Category: Smith M]]
[[Category: Woods VA]]
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