9gcp: Difference between revisions
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==ChREBP/14-3-3 complex stabilized by AMP== | |||
<StructureSection load='9gcp' size='340' side='right'caption='[[9gcp]], [[Resolution|resolution]] 2.59Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9gcp]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GCP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GCP FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.59Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9gcp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gcp OCA], [https://pdbe.org/9gcp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gcp RCSB], [https://www.ebi.ac.uk/pdbsum/9gcp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gcp ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/1433B_HUMAN 1433B_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2.<ref>PMID:17717073</ref> <ref>PMID:19592491</ref> | ||
[[Category: Margulies | == References == | ||
[[Category: Menzer | <references/> | ||
[[Category: Moschref | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Basquin J]] | |||
[[Category: Heimhalt M]] | |||
[[Category: Ladurner AG]] | |||
[[Category: Margulies CE]] | |||
[[Category: Menzer WM]] | |||
[[Category: Moschref M]] | |||
[[Category: Pysik T]] | |||
Latest revision as of 08:13, 13 August 2025
ChREBP/14-3-3 complex stabilized by AMP
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