Squalene synthase

spinqualitylabelsall models Structure of SQS complex with FPP analog and Mg+2 ions (green) (PDB code 3wca). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Squalene synthase (SQS) catalyzes the conversion of 2 molecules of farnesyl pyrophosphate (FPP) to the isoprenoid squalene. SQS is part of the isoprenoid biosynthesis pathway. SQS catalysis is the first step in the sterols synthesis including cholesterol. Dehydrosqualene synthase or phytene synthase catalyzes the condensation of farnesyl diphosphate producing presqualene diphosphate. Relevance SQS inhibitors are tested for antihyperlipidemic and antiatherosclerotic agents. Structural highlights The active site of SQS contains a substrate analog. Water molecules are shown as red spheres. Mg coordination site. 3D structures of squalene synthase Updated on 14-August-2024 {"openlevels":0} Squalene synthase 3vj8, 3vjb – hSQS – human 1ezf – hSQS (mutant) 4hd1 – SQS – Alicyclobacillus acidocaldarius Squalene synthase complexes 3lee – hSQS + Mg + bisphosphonate inhibitor 3asx, 3q2z, 3q30 – hSQS + Mg + PO4 + inhibitor 3vj9, 3vja – hSQS + Ni 3vjc – hSQS + Mg + PO4 + zaragozic acid 3v66 – hSQS + PO4 + inhibitor 3wef – hSQS + FPP analog 3weg – hSQS + Mg + FPP analog 3weh – hSQS + Mg + presqualene pyrophosphate 3wei – hSQS (mutant) + Mn + presqualene pyrophosphate 3wej, 3wek – hSQS (mutant) + Mg + presqualene pyrophosphate 3wc9 – hSQS (mutant) + farnesyl thiopyrophosphate 3wcd – hSQS (mutant) + phenoxy thiocyanate derivative 3wcf, 3wch, 3wci, 3wcl – hSQS (mutant) + imidazole phosphonate derivative 3wcj – hSQS (mutant) + pyrrolidine derivative 3wcm – hSQS (mutant) + pyridine derivative 3wsa, 3wsb – hSQS (mutant) + tuberculosis drug 3wef, 3weg – hSQS + FPP analog 3weh – hSQS + presqualene pyrophosphate 3wei, 3wej, 3wek – hSQS (mutant) + presqualene pyrophosphate 3wca, 3wcb, 3wcc, 3wce, 3wcg – SQS (mutant) + FPP analog – Trypanosoma cruzi 7wgi – AfSQS + PO4 + indole – Aspergillus flavus 7wgh – AfSQS (mutant) + POP + PO4 +farnesyl thiopyrophosphate Dehydrosqualene synthase (DSQS) 3vjd, 2zco – SaDSQS – Staphylococcus aureus 3nri – SaDSQS + dehydrosqualene 3npr, 3adz – SaSQS + presqualene pyrophosphate 3lgz – SaSQS (mutant) + presqualene pyrophosphate 3vje – SaDSQS (mutant) + zaragozic acid 3ae0 – SaDSQS + geranylgeranyl + thiopyrophosphate 3w7f, 5yis – SaDSQS + farnesyl + thiopyrophosphate 3acw, 3acx, 3acy, 3tfv, 3tfn, 3tfp, 4f6v, 4f6x, 2zcs, 2zcq, 2zy1, 2zcr, 4e9z, 4e9u, 4ea0, 4ea1, 4ea2 – SaDSQS + inhibitor

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