1t2s: Difference between revisions

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[[Image:1t2s.gif|left|200px]]
{{Seed}}
[[Image:1t2s.png|left|200px]]


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{{STRUCTURE_1t2s|  PDB=1t2s  |  SCENE=  }}  
{{STRUCTURE_1t2s|  PDB=1t2s  |  SCENE=  }}  


'''Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain'''
===Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain===




==Overview==
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We describe the solution structures of the Argonaute2 PAZ domain bound to RNA and DNA oligonucleotides. The structures reveal a unique mode of single-stranded nucleic acid binding in which the two 3'-terminal nucleotides are buried in a hydrophobic cleft. We propose that the PAZ domain contributes to the specific recognition of siRNAs by providing a binding pocket for their characteristic two-nucleotide 3' overhangs.
The line below this paragraph, {{ABSTRACT_PUBMED_15156196}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15156196 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15156196}}


==About this Structure==
==About this Structure==
1T2S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2S OCA].  
1T2S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2S OCA].  


==Reference==
==Reference==
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[[Category: Dna]]
[[Category: Dna]]
[[Category: Nucleic acid binding protein]]
[[Category: Nucleic acid binding protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 09:26:37 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:54:48 2008''

Revision as of 15:54, 28 July 2008

File:1t2s.png

Template:STRUCTURE 1t2s

Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain

Template:ABSTRACT PUBMED 15156196

About this Structure

1T2S is a Single protein structure of sequence from Drosophila melanogaster. Full experimental information is available from OCA.

Reference

Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain., Lingel A, Simon B, Izaurralde E, Sattler M, Nat Struct Mol Biol. 2004 Jun;11(6):576-7. Epub 2004 May 23. PMID:15156196

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