9j1s: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9j1s is ~~ON HOLD until Paper Publication~~

==Human replication protein A: RPA70 subunit N-terminal domain==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9j1s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9J1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9J1S FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9j1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9j1s OCA], [https://pdbe.org/9j1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9j1s RCSB], [https://www.ebi.ac.uk/pdbsum/9j1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9j1s ProSAT]</span></td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/RFA1_HUMAN RFA1_HUMAN] Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref> Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Chakraborty M]]

[[Category: Das AK]]

[[Category: Ganguly A]]

[[Category: Ganguly SS]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9j1s is ON HOLD  until Paper Publication
+==Human replication protein A: RPA70 subunit N-terminal domain==
+<StructureSection load='9j1s' size='340' side='right'caption='[[9j1s]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9j1s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9J1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9J1S FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9j1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9j1s OCA], [https://pdbe.org/9j1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9j1s RCSB], [https://www.ebi.ac.uk/pdbsum/9j1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9j1s ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RFA1_HUMAN RFA1_HUMAN] Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref>   Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Chakraborty M]]
+[[Category: Das AK]]
+[[Category: Ganguly A]]
+[[Category: Ganguly SS]]