1wu1: Difference between revisions

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New page: left|200px<br /> <applet load="1wu1" size="450" color="white" frame="true" align="right" spinBox="true" caption="1wu1, resolution 2.30Å" /> '''Factor Xa in comple...
 
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[[Image:1wu1.gif|left|200px]]<br />
[[Image:1wu1.gif|left|200px]]<br /><applet load="1wu1" size="350" color="white" frame="true" align="right" spinBox="true"  
<applet load="1wu1" size="450" color="white" frame="true" align="right" spinBox="true"  
caption="1wu1, resolution 2.30&Aring;" />
caption="1wu1, resolution 2.30&Aring;" />
'''Factor Xa in complex with the inhibitor 4-[(5-chloroindol-2-yl)sulfonyl]-2-(2-methylpropyl)-1-[[5-(pyridin-4-yl) pyrimidin-2-yl]carbonyl]piperazine'''<br />
'''Factor Xa in complex with the inhibitor 4-[(5-chloroindol-2-yl)sulfonyl]-2-(2-methylpropyl)-1-[[5-(pyridin-4-yl) pyrimidin-2-yl]carbonyl]piperazine'''<br />


==Overview==
==Overview==
Compound 7 was identified as the active metabolite of 6 by HPLC and mass, spectral analysis. Modification of lead compound 7 by transformation of, its N-oxide 6-6 biaryl ring system and fused aromatics produced a series, of non-basic fXa inhibitors with excellent potency in anti-fXa and, anticoagulant assays. The optimized compounds 73b and 75b showed sub to, one digit micromolar anticoagulant activity (PTCT2). Particularly, anti-fXa activity was detected in plasma of rats orally administered with, 1mg/kg of compound 75b.
Compound 7 was identified as the active metabolite of 6 by HPLC and mass spectral analysis. Modification of lead compound 7 by transformation of its N-oxide 6-6 biaryl ring system and fused aromatics produced a series of non-basic fXa inhibitors with excellent potency in anti-fXa and anticoagulant assays. The optimized compounds 73b and 75b showed sub to one digit micromolar anticoagulant activity (PTCT2). Particularly, anti-fXa activity was detected in plasma of rats orally administered with 1mg/kg of compound 75b.


==Disease==
==Disease==
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==About this Structure==
==About this Structure==
1WU1 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA and D91 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1WU1 OCA].  
1WU1 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=D91:'>D91</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WU1 OCA].  


==Reference==
==Reference==
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[[Category: serine protease]]
[[Category: serine protease]]


''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:54:54 2007''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:48:04 2008''