9gio: Difference between revisions
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==Crystal structure of the VHL-EloC-EloB complex with a covalent compound bound to C77 of VHL.== | |||
<StructureSection load='9gio' size='340' side='right'caption='[[9gio]], [[Resolution|resolution]] 1.49Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9gio]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GIO FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.486Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3JF:N-ACETYL-3-METHYL-L-VALYL-(4R)-4-HYDROXY-N-[4-(4-METHYL-1,3-THIAZOL-5-YL)BENZYL]-L-PROLINAMIDE'>3JF</scene>, <scene name='pdbligand=A1IMD:~{N}-[2-(dimethylsulfamoyl)-5-[(1-methylpyrazol-4-yl)methoxy]phenyl]propanamide'>A1IMD</scene></td></tr> | ||
[[Category: Collie | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9gio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gio OCA], [https://pdbe.org/9gio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gio RCSB], [https://www.ebi.ac.uk/pdbsum/9gio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gio ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ELOB_HUMAN ELOB_HUMAN] SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).<ref>PMID:7638163</ref> <ref>PMID:15590694</ref> The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.<ref>PMID:7638163</ref> <ref>PMID:15590694</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Collie GW]] | |||
Latest revision as of 21:48, 26 March 2025
Crystal structure of the VHL-EloC-EloB complex with a covalent compound bound to C77 of VHL.
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