1t4v: Difference between revisions

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Bots, Bureaucrats, journal, Administrators
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OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,438 edits
No edit summary
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[[Image:1t4v.gif|left|200px]]
{{Seed}}
[[Image:1t4v.png|left|200px]]


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{{STRUCTURE_1t4v|  PDB=1t4v  |  SCENE=  }}  
{{STRUCTURE_1t4v|  PDB=1t4v  |  SCENE=  }}  


'''Crystal Structure Analysis of a novel Oxyguanidine bound to Thrombin'''
===Crystal Structure Analysis of a novel Oxyguanidine bound to Thrombin===




==Overview==
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Through structure-based drug design and parallel synthesis, we have discovered a novel series of nonpeptidic phenyl-based thrombin inhibitors using oxyguanidines as guanidine bioisosteres. These compounds have been found to be highly potent, highly selective, and orally bioavailable.
The line below this paragraph, {{ABSTRACT_PUBMED_15203151}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15203151 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15203151}}


==Disease==
==Disease==
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[[Category: Spurlino, J.]]
[[Category: Spurlino, J.]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 09:31:51 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:36:24 2008''
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