1t51: Difference between revisions

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[[Image:1t51.gif|left|200px]]
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[[Image:1t51.png|left|200px]]


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{{STRUCTURE_1t51|  PDB=1t51  |  SCENE=  }}  
{{STRUCTURE_1t51|  PDB=1t51  |  SCENE=  }}  


'''Antibiotic Activity and Structural Analysis of a Scorpion-derived Antimicrobial peptide IsCT and Its Analogs'''
===Antibiotic Activity and Structural Analysis of a Scorpion-derived Antimicrobial peptide IsCT and Its Analogs===




==Overview==
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IsCT is a non-cell-selective antimicrobial peptide isolated from the scorpion Opisthacanthus madagascariensis that has potent cytolytic activity against both mammalian and bacterial cells. To investigate the structure-activity relationships of IsCT and to design novel peptide antibiotics with bacterial cell selectivity, we synthesized several analogs of IsCT and determined their three-dimensional structures in solution by 2D-NMR spectroscopy. IsCT has a linear alpha-helical structure from Gly3 to Phe13, and [K7]-IsCT has a linear alpha-helical structure from Leu2 to Phe13. [K7, P8, K11]-IsCT, which has a bend in its middle region, exhibited the highest antibacterial activity without hemolytic activity, suggesting that its proline-induced bend is an important determinant of this selectivity. Tryptophan fluorescence showed that the high selectivity of [K7, P8, K11]-IsCT toward bacterial cells is closely correlated with its highly selective interaction with negatively charged phospholipids. Its potent activity against antibiotic-resistant bacteria suggests that [K7, P8, K11]-IsCT may serve as a promising lead candidate in the development of new peptide antibiotics.
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{{ABSTRACT_PUBMED_15369808}}


==About this Structure==
==About this Structure==
1T51 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Opisthacanthus_madagascariensis Opisthacanthus madagascariensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T51 OCA].  
1T51 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Opisthacanthus_madagascariensis Opisthacanthus madagascariensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T51 OCA].  


==Reference==
==Reference==
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[[Category: Shin, S Y.]]
[[Category: Shin, S Y.]]
[[Category: Coil-helix]]
[[Category: Coil-helix]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 09:32:18 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:05:13 2008''

Revision as of 06:05, 28 July 2008

File:1t51.png

Template:STRUCTURE 1t51

Antibiotic Activity and Structural Analysis of a Scorpion-derived Antimicrobial peptide IsCT and Its Analogs

Template:ABSTRACT PUBMED 15369808

About this Structure

1T51 is a Single protein structure of sequence from Opisthacanthus madagascariensis. Full experimental information is available from OCA.

Reference

Antibiotic activity and structural analysis of the scorpion-derived antimicrobial peptide IsCT and its analogs., Lee K, Shin SY, Kim K, Lim SS, Hahm KS, Kim Y, Biochem Biophys Res Commun. 2004 Oct 15;323(2):712-9. PMID:15369808

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