9de2: Difference between revisions

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'''Unreleased structure'''


The entry 9de2 is ON HOLD
==ETO2 MYND bound to MPPL peptide from GATAD2A==
 
<StructureSection load='9de2' size='340' side='right'caption='[[9de2]]' scene=''>
Authors: Williams, D.C.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9de2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9DE2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9DE2 FirstGlance]. <br>
Description: ETO2 MYND bound to MPPL peptide from GATAD2A
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Williams, D.C]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9de2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9de2 OCA], [https://pdbe.org/9de2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9de2 RCSB], [https://www.ebi.ac.uk/pdbsum/9de2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9de2 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/MTG16_HUMAN MTG16_HUMAN] Acute megakaryoblastic leukemia in children without Down syndrome. A chromosomal aberration involving CBFA2T3 is found in therapy-related myeloid malignancies. Translocation t(16;21)(q24;q22) that forms a RUNX1-CBFA2T3 fusion protein.<ref>PMID:10995019</ref> <ref>PMID:11224496</ref> <ref>PMID:9596646</ref>
== Function ==
[https://www.uniprot.org/uniprot/MTG16_HUMAN MTG16_HUMAN] Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed:23840896, PubMed:25974097). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Plays a role in granulocyte differentiation (PubMed:15231665).[UniProtKB:O54972]<ref>PMID:12183414</ref> <ref>PMID:15231665</ref> <ref>PMID:16966434</ref> <ref>PMID:23251453</ref> <ref>PMID:23840896</ref> <ref>PMID:25974097</ref> <ref>PMID:12559562</ref> <ref>PMID:15203199</ref>  Isoform 2 functions as an A-kinase-anchoring protein (PubMed:11823486).<ref>PMID:11823486</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Williams DC]]
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