9ix2: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9ix2 is ~~ON HOLD until Paper Publication~~

==Crystal structure of the mouse RIP3 kinase domain in complexed with TAK-632==

~~Authors~~: ~~Xie~~, H., ~~Su, H~~.X., Li, M.J., Xu, Y.C.

== Structural highlights ==

<table><tr><td colspan='2'>[[9ix2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9IX2 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9IX2 FirstGlance].

~~Description~~: ~~Crystal structure~~ of the ~~mouse RIP3 kinase domain~~ in ~~complexed with TAK-632~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.39Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1SU:N-{7-CYANO-6-[4-FLUORO-3-({[3-(TRIFLUOROMETHYL)PHENYL]ACETYL}AMINO)PHENOXY]-1,3-BENZOTHIAZOL-2-YL}CYCLOPROPANECARBOXAMIDE'>1SU</scene></td></tr>

[[Category: ~~Su, H.X~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9ix2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ix2 OCA], [https://pdbe.org/9ix2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ix2 RCSB], [https://www.ebi.ac.uk/pdbsum/9ix2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ix2 ProSAT]</td></tr>

[[Category: ~~Xie, H~~]]

</table>

[[Category: ~~Li, M.J~~]]

== Function ==

[[Category: Xu~~, Y.C~~]]

[https://www.uniprot.org/uniprot/RIPK3_MOUSE RIPK3_MOUSE] Essential for programmed necrosis in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (By similarity).<ref>PMID:19590578</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Mus musculus]]

[[Category: Li MJ]]

[[Category: Su HX]]

[[Category: Xie H]]

[[Category: Xu YC]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9ix2 is ON HOLD  until Paper Publication
+==Crystal structure of the mouse RIP3 kinase domain in complexed with TAK-632==
+<StructureSection load='9ix2' size='340' side='right'caption='[[9ix2]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
-Authors: Xie, H., Su, H.X., Li, M.J., Xu, Y.C.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9ix2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9IX2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9IX2 FirstGlance]. <br>
-Description: Crystal structure of the mouse RIP3 kinase domain in complexed with TAK-632
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.39&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1SU:N-{7-CYANO-6-[4-FLUORO-3-({[3-(TRIFLUOROMETHYL)PHENYL]ACETYL}AMINO)PHENOXY]-1,3-BENZOTHIAZOL-2-YL}CYCLOPROPANECARBOXAMIDE'>1SU</scene></td></tr>
-[[Category: Su, H.X]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ix2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ix2 OCA], [https://pdbe.org/9ix2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ix2 RCSB], [https://www.ebi.ac.uk/pdbsum/9ix2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ix2 ProSAT]</span></td></tr>
-[[Category: Xie, H]]
+</table>
-[[Category: Li, M.J]]
+== Function ==
-[[Category: Xu, Y.C]]
+[https://www.uniprot.org/uniprot/RIPK3_MOUSE RIPK3_MOUSE] Essential for programmed necrosis in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (By similarity).<ref>PMID:19590578</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Li MJ]]
+[[Category: Su HX]]
+[[Category: Xie H]]
+[[Category: Xu YC]]