Activin receptor

spinqualitylabelsall models Human Acvr1 kinase domain complex with inhibitor, ethylene glycol and citrate (PDB code 4bgg) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Activin receptors (Acvr) are integral to the activin and myostatin signalling pathway. Binding of activin to the Acvr on muscle cell membrane leads to enhanced muscle protein breakdown and debilitating loss of muscle mass and functional capacity. Acvr1 is involved in bone, heart, cartilage, nervous and reproductive system development and regulation. See also: Enzyme-linked receptor. Disease A mutation in Acvr1 exists in individuals with the rare developmental disorder fibrodysplasia ossificans progressiva. Relevance Increased activin/Acvr2 signalling links aging and heart failure pathobiology and that targeted inhibition of this catabolic pathway may form a therapeutic strategy for multiple forms of hear failure. Structural highlights 3D structure of the kinase domain of Acvr1 complex with inhibitor shows the inhibitor forming various interactions with the protein including a hydrogen bonds to His residues and a water bridged hydrogen bond to the catalytic lysine. Water molecule is shown as red sphere. 3D structures of activin receptor Activin receptor 3D structures

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