9cze: Difference between revisions

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'''Unreleased structure'''


The entry 9cze is ON HOLD  until Paper Publication
==High-Resolution Structure of Human DHODH for Molecular Replacement in Fragment Screening Campaign==
 
<StructureSection load='9cze' size='340' side='right'caption='[[9cze]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
Authors: Purificacao, A.D., Benz, L.S., Froes, T.Q., Weiss, M.S., Nonato, M.C.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9cze]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9CZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9CZE FirstGlance]. <br>
Description: High-Resolution Structure of Human DHODH for Molecular Replacement in Fragment Screening Campaign
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Weiss, M.S]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9cze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9cze OCA], [https://pdbe.org/9cze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9cze RCSB], [https://www.ebi.ac.uk/pdbsum/9cze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9cze ProSAT]</span></td></tr>
[[Category: Froes, T.Q]]
</table>
[[Category: Nonato, M.C]]
== Disease ==
[[Category: Benz, L.S]]
[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[https://omim.org/entry/263750 263750]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>
[[Category: Purificacao, A.D]]
== Function ==
[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Benz LS]]
[[Category: Froes TQ]]
[[Category: Nonato MC]]
[[Category: Purificacao AD]]
[[Category: Weiss MS]]
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