1t6v: Difference between revisions

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[[Image:1t6v.gif|left|200px]]
{{Seed}}
[[Image:1t6v.png|left|200px]]


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{{STRUCTURE_1t6v|  PDB=1t6v  |  SCENE=  }}  
{{STRUCTURE_1t6v|  PDB=1t6v  |  SCENE=  }}  


'''Crystal structure analysis of the nurse shark new antigen receptor (NAR) variable domain in complex with lysozyme'''
===Crystal structure analysis of the nurse shark new antigen receptor (NAR) variable domain in complex with lysozyme===




==Overview==
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Cartilaginous fish are the phylogenetically oldest living organisms known to possess components of the vertebrate adaptive immune system. Key to their immune response are heavy-chain, homodimeric immunoglobulins called new antigen receptors (IgNARs), in which the variable (V) domains recognize antigens with only a single immunoglobulin domain, akin to camelid heavy-chain V domains. The 1.45 angstrom resolution crystal structure of the type I IgNAR V domain in complex with hen egg-white lysozyme (HEL) reveals a minimal antigen-binding domain that contains only two of the three conventional complementarity-determining regions but still binds HEL with nanomolar affinity by means of a binding interface comparable in size to conventional antibodies.
The line below this paragraph, {{ABSTRACT_PUBMED_15319492}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15319492 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15319492}}


==About this Structure==
==About this Structure==
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[[Category: Immunoglobulin fold]]
[[Category: Immunoglobulin fold]]
[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 09:36:17 2008''
 
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