9gp7: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9gp7 is ~~ON HOLD~~

==Cryo EM structure of the E307T mutant of the human P2X4 receptor in complex with the anthraquinone derivative PSB-0704==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9gp7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GP7 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9GP7 FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.35Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1INJ:1-azanyl-4-[(3-carboxy-4-phenylazanyl-phenyl)amino]-9,10-bis(oxidanylidene)anthracene-2-carboxylic+acid'>A1INJ</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9gp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gp7 OCA], [https://pdbe.org/9gp7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gp7 RCSB], [https://www.ebi.ac.uk/pdbsum/9gp7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gp7 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/P2RX4_HUMAN P2RX4_HUMAN] ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed:9016352). CTP, but not GTP or UTP, functions as a weak affinity agonist for P2RX4 (By similarity). Activated by extracellularly released ATP, it plays multiple role in immunity and central nervous system physiology (PubMed:35165166). Plays a key role in initial steps of T-cell activation and Ca(2+) microdomain formation (By similarity). Participates also in basal T-cell activity without TCR/CD3 stimulation (By similarity). Promotes the differentiation and activation of Th17 cells via expression of retinoic acid-related orphan receptor C/RORC (PubMed:35165166). Upon activation, drives microglia motility via the PI3K/Akt pathway (By similarity). Could also function as an ATP-gated cation channel of lysosomal membranes (By similarity).[UniProtKB:P51577][UniProtKB:Q9JJX6]<ref>PMID:35165166</ref> <ref>PMID:9016352</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Claff T]]

[[Category: Geyer M]]

[[Category: Hagelueken G]]

[[Category: Mueller CE]]

[[Category: Nagel J]]

[[Category: Torp J]]

[[Category: Vaaen V]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9gp7 is ON HOLD
+==Cryo EM structure of the E307T mutant of the human P2X4 receptor in complex with the anthraquinone derivative PSB-0704==
+<StructureSection load='9gp7' size='340' side='right'caption='[[9gp7]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9gp7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GP7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GP7 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.35&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1INJ:1-azanyl-4-[(3-carboxy-4-phenylazanyl-phenyl)amino]-9,10-bis(oxidanylidene)anthracene-2-carboxylic+acid'>A1INJ</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9gp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gp7 OCA], [https://pdbe.org/9gp7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gp7 RCSB], [https://www.ebi.ac.uk/pdbsum/9gp7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gp7 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/P2RX4_HUMAN P2RX4_HUMAN] ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed:9016352). CTP, but not GTP or UTP, functions as a weak affinity agonist for P2RX4 (By similarity). Activated by extracellularly released ATP, it plays multiple role in immunity and central nervous system physiology (PubMed:35165166). Plays a key role in initial steps of T-cell activation and Ca(2+) microdomain formation (By similarity). Participates also in basal T-cell activity without TCR/CD3 stimulation (By similarity). Promotes the differentiation and activation of Th17 cells via expression of retinoic acid-related orphan receptor C/RORC (PubMed:35165166). Upon activation, drives microglia motility via the PI3K/Akt pathway (By similarity). Could also function as an ATP-gated cation channel of lysosomal membranes (By similarity).[UniProtKB:P51577][UniProtKB:Q9JJX6]<ref>PMID:35165166</ref> <ref>PMID:9016352</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Claff T]]
+[[Category: Geyer M]]
+[[Category: Hagelueken G]]
+[[Category: Mueller CE]]
+[[Category: Nagel J]]
+[[Category: Torp J]]
+[[Category: Vaaen V]]