9ixu: Difference between revisions
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==Overall reconstruction of the Bax line== | |||
<StructureSection load='9ixu' size='340' side='right'caption='[[9ixu]], [[Resolution|resolution]] 3.19Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9ixu]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9IXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9IXU FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.19Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ixu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ixu OCA], [https://pdbe.org/9ixu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ixu RCSB], [https://www.ebi.ac.uk/pdbsum/9ixu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ixu ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BAX_HUMAN BAX_HUMAN] Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.<ref>PMID:8358790</ref> <ref>PMID:10772918</ref> <ref>PMID:8521816</ref> <ref>PMID:16113678</ref> <ref>PMID:18948948</ref> <ref>PMID:21199865</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Ge X]] | |||
[[Category: Huang G]] | |||
[[Category: Shi Y]] | |||
[[Category: Tian L]] | |||
[[Category: Zhang Y]] | |||
Latest revision as of 11:05, 18 June 2025
Overall reconstruction of the Bax line
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