9j5x: Difference between revisions

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'''Unreleased structure'''


The entry 9j5x is ON HOLD  until Paper Publication
==Cryo-EM Structure of URAT1 in Complex with Verinurad==
 
<StructureSection load='9j5x' size='340' side='right'caption='[[9j5x]], [[Resolution|resolution]] 3.44&Aring;' scene=''>
Authors: Fan, J., Lei, X.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9j5x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9J5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9J5X FirstGlance]. <br>
Description: Cryo-EM structure of UC10_L
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.44&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EAP:3-bromanyl-5-(2-ethylimidazo[1,2-a]pyridin-3-yl)carbonyl-2-oxidanyl-benzenecarbonitrile'>A1EAP</scene></td></tr>
[[Category: Lei, X]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9j5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9j5x OCA], [https://pdbe.org/9j5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9j5x RCSB], [https://www.ebi.ac.uk/pdbsum/9j5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9j5x ProSAT]</span></td></tr>
[[Category: Fan, J]]
</table>
== Function ==
[https://www.uniprot.org/uniprot/S22AC_RAT S22AC_RAT] Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions (PubMed:21074513). Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid (PubMed:21074513). Mediates urate uptake by an exchange with organic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-) (PubMed:21074513). Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate (By similarity). Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption. Orotate transport is Cl(-)-dependent (By similarity).[UniProtKB:Q96S37]<ref>PMID:21074513</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Fan J]]
[[Category: Lei X]]
Retrieved from "https://proteopedia.org/9j5x"