9dpf: Difference between revisions
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==Crystal structure of TMPRSS11D S368A complexed with its own zymogen activation motif== | |||
<StructureSection load='9dpf' size='340' side='right'caption='[[9dpf]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9dpf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9DPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9DPF FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9dpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9dpf OCA], [https://pdbe.org/9dpf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9dpf RCSB], [https://www.ebi.ac.uk/pdbsum/9dpf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9dpf ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/TM11D_HUMAN TM11D_HUMAN] May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate.<ref>PMID:23536651</ref> <ref>PMID:24227843</ref> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith C]] | |||
[[Category: Benard F]] | |||
[[Category: Dong A]] | |||
[[Category: Edwards A]] | |||
[[Category: Fraser BJ]] | |||
[[Category: Ilyassov O]] | |||
[[Category: Li Y]] | |||
[[Category: Seitova A]] | |||
Latest revision as of 04:18, 17 October 2024
Crystal structure of TMPRSS11D S368A complexed with its own zymogen activation motif
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