9jjb: Difference between revisions

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'''Unreleased structure'''


The entry 9jjb is ON HOLD  until Paper Publication
==Class 1 state of the GfsA KSQ-ancestralAT chimeric didomain in complex with the GfsA ACP domain==
 
<StructureSection load='9jjb' size='340' side='right'caption='[[9jjb]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9jjb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_graminofaciens Streptomyces graminofaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JJB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JJB FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.68&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9EF:[(3~{R})-4-[[3-(2-acetamidoethylamino)-3-oxidanylidene-propyl]amino]-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-butyl]+dihydrogen+phosphate'>9EF</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jjb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jjb OCA], [https://pdbe.org/9jjb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jjb RCSB], [https://www.ebi.ac.uk/pdbsum/9jjb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jjb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GFSA_STRHA GFSA_STRHA] First protein in the synthesis of the 16-membered macrolide antibiotics FD-891 and FD-892 (PubMed:20589823). Composed of 5 modules; the first is a loading module (LM) that synthesizes a starter unit used by the first elongation module for polyketide chain elongation (PubMed:34985877, PubMed:37216195). The starter unit is extended by multiple rounds of addition of malonyl-CoA or methylmalonyl-CoA, and other modifications to help generate the final products (Probable) (PubMed:20589823). The loading module (residues 1-927, LM with an inactive acyltransferase domain) preferentially decarboxylates malonyl-GfsA acyl carrier protein of the LM (ACP-LM) over methylmalonyl-GfsA ACP-LM and has no activity on malonyl-CoA or methymalonyl-CoA (PubMed:34985877). LM decarboxylates malonyl-ACP-LM better than the malonyl-ACP-1 module of GfsA (i.e. the next module in the same protein) and has no activity on other malonyl-ACP modules (PubMed:37216195).<ref>PMID:20589823</ref> <ref>PMID:34985877</ref> <ref>PMID:37216195</ref> <ref>PMID:20589823</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Streptomyces graminofaciens]]
[[Category: Adachi N]]
[[Category: Chisuga T]]
[[Category: Eguchi T]]
[[Category: Kawasaki M]]
[[Category: Kudo F]]
[[Category: Liao Z]]
[[Category: Miyanaga A]]
[[Category: Moriya T]]
[[Category: Senda T]]
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