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'''Unreleased structure'''


The entry 9jqt is ON HOLD
==Structure of interleukin receptor common gamma chain (IL2Rgamma/CD132) in complex with 2D4==
 
<StructureSection load='9jqt' size='340' side='right'caption='[[9jqt]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
Authors: Lu, Q.J., Yin, H.Q.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9jqt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JQT FirstGlance]. <br>
Description: Structure of interleukin receptor common gamma chain (IL2Rgamma/CD132) in complex with 2D4
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jqt OCA], [https://pdbe.org/9jqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jqt RCSB], [https://www.ebi.ac.uk/pdbsum/9jqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jqt ProSAT]</span></td></tr>
[[Category: Yin, H.Q]]
</table>
[[Category: Lu, Q.J]]
== Disease ==
[https://www.uniprot.org/uniprot/IL2RG_HUMAN IL2RG_HUMAN] Defects in IL2RG are the cause of severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell-negative (XSCID) [MIM:[https://omim.org/entry/300400 300400]; also known as agammaglobulinemia Swiss type. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.<ref>PMID:8401490</ref> <ref>PMID:8299698</ref> <ref>PMID:8088810</ref> <ref>PMID:8027558</ref> <ref>PMID:7937790</ref> <ref>PMID:7668284</ref> <ref>PMID:7557965</ref> <ref>PMID:7860773</ref> <ref>PMID:8900089</ref> <ref>PMID:9150740</ref>  Defects in IL2RG are the cause of X-linked combined immunodeficiency (XCID) [MIM:[https://omim.org/entry/312863 312863]. XCID is a less severe form of X-linked immunodeficiency with a less severe degree of deficiency in cellular and humoral immunity than that seen in XSCID.<ref>PMID:7883965</ref> <ref>PMID:9399950</ref>
== Function ==
[https://www.uniprot.org/uniprot/IL2RG_HUMAN IL2RG_HUMAN] Common subunit for the receptors for a variety of interleukins.
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Lu QJ]]
[[Category: Yin HQ]]
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