1tf6: Difference between revisions

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[[Image:1tf6.~~jpg~~|left|200px]]

[[Image:1tf6.png|left|200px]]

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~~==Overview==~~

The crystal structure of the six NH2-terminal zinc fingers of Xenopus laevis transcription factor IIIA (TFIIIA) bound with 31 bp of the 5S rRNA gene promoter has been determined at 3.1 A resolution. Individual zinc fingers are positioned differently in the major groove and across the minor groove of DNA to span the entire length of the duplex. These results show how TFIIIA can recognize several separated DNA sequences by using fewer fingers than necessary for continuous winding in the major groove.

==About this Structure==

1TF6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. The following page contains interesting information on the relation of 1TF6 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb87_1.html Zinc Fingers]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TF6 OCA].

~~==Reference==~~

Differing roles for zinc fingers in DNA recognition: structure of a six-finger transcription factor IIIA complex., Nolte RT, Conlin RM, Harrison SC, Brown RS, Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2938-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9501194 9501194]

[[Category: Single protein]]

[[Category: Xenopus laevis]]

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[[Category: Transcription initiation]]

[[Category: Zinc finger protein]]

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-[[Image:1tf6.jpg|left|200px]]
+[[Image:1tf6.png|left|200px]]
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-==Overview==
+{{ABSTRACT_9501194}}
-The crystal structure of the six NH2-terminal zinc fingers of Xenopus laevis transcription factor IIIA (TFIIIA) bound with 31 bp of the 5S rRNA gene promoter has been determined at 3.1 A resolution. Individual zinc fingers are positioned differently in the major groove and across the minor groove of DNA to span the entire length of the duplex. These results show how TFIIIA can recognize several separated DNA sequences by using fewer fingers than necessary for continuous winding in the major groove.
 ==About this Structure==
 TF6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. The following page contains interesting information on the relation of 1TF6 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb87_1.html Zinc Fingers]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TF6 OCA].
-==Reference==
-Differing roles for zinc fingers in DNA recognition: structure of a six-finger transcription factor IIIA complex., Nolte RT, Conlin RM, Harrison SC, Brown RS, Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2938-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9501194 9501194]
 [[Category: Single protein]]
 [[Category: Xenopus laevis]]
@@ Line 30: / Line 26: @@
 [[Category: Transcription initiation]]
 [[Category: Zinc finger protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 09:52:47 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:00:33 2008''