1tfg: Difference between revisions

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[[Image:1tfg.gif|left|200px]]
{{Seed}}
[[Image:1tfg.png|left|200px]]


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{{STRUCTURE_1tfg|  PDB=1tfg  |  SCENE=  }}  
{{STRUCTURE_1tfg|  PDB=1tfg  |  SCENE=  }}  


'''AN UNUSUAL FEATURE REVEALED BY THE CRYSTAL STRUCTURE AT 2.2 ANGSTROMS RESOLUTION OF HUMAN TRANSFORMING GROWTH FACTOR-BETA2'''
===AN UNUSUAL FEATURE REVEALED BY THE CRYSTAL STRUCTURE AT 2.2 ANGSTROMS RESOLUTION OF HUMAN TRANSFORMING GROWTH FACTOR-BETA2===




==Overview==
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Transforming growth factor type beta 2 (TGF-beta 2) is a member of an expanding family of growth factors that regulate proliferation and differentiation of many different cell types. TGF-beta 2 binds to various receptors, one of which was shown to be a serine/threonine kinase. TGF-beta 2 is involved in wound healing, bone formation and modulation of immune functions. We report here the crystal structure of TGF-beta 2 at 2.2 A resolution, which reveals a novel monomer fold and dimer association. The monomer consists of two antiparallel pairs of beta-strands forming a flat curved surface and a separate, long alpha-helix. The disulphide-rich core has one disulphide bone pointing through a ring formed by the sequence motifs Cys-Ala-Gly-Ala-Cys and Cys-Lys-Cys, which are themselves connected through the cysteines. Two monomers are connected through a single disulphide bridge and associate such that the helix of one subunit interacts with the concave beta-sheet surface of the other. Four exposed loop regions might determine receptor specificity. The structure provides a suitable model for the TGF-beta s and other members of the super-family and is the basis for the analysis of the TGF-beta 2 interactions with the receptor.
The line below this paragraph, {{ABSTRACT_PUBMED_1641027}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 1641027 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1641027}}


==About this Structure==
==About this Structure==
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[[Category: Schlunegger, M.]]
[[Category: Schlunegger, M.]]
[[Category: Growth factor]]
[[Category: Growth factor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 09:53:15 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:31:41 2008''

Revision as of 09:31, 29 July 2008

File:1tfg.png

Template:STRUCTURE 1tfg

AN UNUSUAL FEATURE REVEALED BY THE CRYSTAL STRUCTURE AT 2.2 ANGSTROMS RESOLUTION OF HUMAN TRANSFORMING GROWTH FACTOR-BETA2

Template:ABSTRACT PUBMED 1641027

About this Structure

1TFG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

An unusual feature revealed by the crystal structure at 2.2 A resolution of human transforming growth factor-beta 2., Schlunegger MP, Grutter MG, Nature. 1992 Jul 30;358(6385):430-4. PMID:1641027

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