1tg8: Difference between revisions

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[[Image:1tg8.~~gif~~|left|200px]]

[[Image:1tg8.png|left|200px]]

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~~'''~~The structure of Dengue virus E glycoprotein~~'''~~

===The structure of Dengue virus E glycoprotein===

~~==Overview==~~

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~~Dengue virus~~, ~~a member of the Flaviviridae family~~, ~~has a surface composed of 180 copies each of~~ the ~~envelope (E) glycoprotein and~~ the ~~membrane~~ (~~M) protein~~. ~~The crystal structure of an N-terminal fragment of E has been determined and compared with a previously described structure~~. ~~The primary difference between these structures~~ is ~~a 10 degrees rotation about a hinge relating~~ the ~~fusion domain DII to domains DI and DIII~~. ~~These two rigid body components were used for independent fitting of E into the cryo~~-electron microscopy maps of both immature and mature dengue viruses. The fitted E structures in these two particles showed a difference of 27 degrees between the two components. Comparison of the E structure in its postfusion state with that in the immature and mature virions shows a rotation approximately around the same hinge. Flexibility of E is apparently a functional requirement for assembly and infection of flaviviruses.

The line below this paragraph, {{ABSTRACT_PUBMED_15341726}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 15341726 is the PubMed ID number.

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==About this Structure==

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[[Category: Zhang, Y.]]

[[Category: Flavivirus e conformation]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 09~~:55:06 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:29:00 2008''

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-[[Image:1tg8.gif|left|200px]]
+{{Seed}}
+[[Image:1tg8.png|left|200px]]
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 {{STRUCTURE_1tg8|  PDB=1tg8  |  SCENE=  }}
-'''The structure of Dengue virus E glycoprotein'''
+===The structure of Dengue virus E glycoprotein===
-==Overview==
+<!--
-Dengue virus, a member of the Flaviviridae family, has a surface composed of 180 copies each of the envelope (E) glycoprotein and the membrane (M) protein. The crystal structure of an N-terminal fragment of E has been determined and compared with a previously described structure. The primary difference between these structures is a 10 degrees rotation about a hinge relating the fusion domain DII to domains DI and DIII. These two rigid body components were used for independent fitting of E into the cryo-electron microscopy maps of both immature and mature dengue viruses. The fitted E structures in these two particles showed a difference of 27 degrees between the two components. Comparison of the E structure in its postfusion state with that in the immature and mature virions shows a rotation approximately around the same hinge. Flexibility of E is apparently a functional requirement for assembly and infection of flaviviruses.
+The line below this paragraph, {{ABSTRACT_PUBMED_15341726}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15341726 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15341726}}
 ==About this Structure==
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 [[Category: Zhang, Y.]]
 [[Category: Flavivirus e conformation]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 09:55:06 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:29:00 2008''