1tge: Difference between revisions

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[[Image:1tge.~~gif~~|left|200px]]

[[Image:1tge.png|left|200px]]

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~~'''~~The structure of immature Dengue virus at 12.5 angstrom~~'''~~

===The structure of immature Dengue virus at 12.5 angstrom===

~~==Overview==~~

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~~Dengue virus~~, ~~a member of the Flaviviridae family~~, ~~has a surface composed of 180 copies each of~~ the ~~envelope (E) glycoprotein and~~ the ~~membrane~~ (~~M) protein~~. ~~The crystal structure of an N-terminal fragment of E has been determined and compared with a previously described structure~~. ~~The primary difference between these structures~~ is ~~a 10 degrees rotation about a hinge relating~~ the ~~fusion domain DII to domains DI and DIII~~. ~~These two rigid body components were used for independent fitting of E into the cryo~~-electron microscopy maps of both immature and mature dengue viruses. The fitted E structures in these two particles showed a difference of 27 degrees between the two components. Comparison of the E structure in its postfusion state with that in the immature and mature virions shows a rotation approximately around the same hinge. Flexibility of E is apparently a functional requirement for assembly and infection of flaviviruses.

The line below this paragraph, {{ABSTRACT_PUBMED_15341726}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 15341726 is the PubMed ID number.

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==About this Structure==

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[[Category: Icosahedral virus]]

[[Category: Prm particle]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 09~~:55:19 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:45:37 2008''

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-[[Image:1tge.gif|left|200px]]
+{{Seed}}
+[[Image:1tge.png|left|200px]]
 <!--
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 {{STRUCTURE_1tge|  PDB=1tge  |  SCENE=  }}
-'''The structure of immature Dengue virus at 12.5 angstrom'''
+===The structure of immature Dengue virus at 12.5 angstrom===
-==Overview==
+<!--
-Dengue virus, a member of the Flaviviridae family, has a surface composed of 180 copies each of the envelope (E) glycoprotein and the membrane (M) protein. The crystal structure of an N-terminal fragment of E has been determined and compared with a previously described structure. The primary difference between these structures is a 10 degrees rotation about a hinge relating the fusion domain DII to domains DI and DIII. These two rigid body components were used for independent fitting of E into the cryo-electron microscopy maps of both immature and mature dengue viruses. The fitted E structures in these two particles showed a difference of 27 degrees between the two components. Comparison of the E structure in its postfusion state with that in the immature and mature virions shows a rotation approximately around the same hinge. Flexibility of E is apparently a functional requirement for assembly and infection of flaviviruses.
+The line below this paragraph, {{ABSTRACT_PUBMED_15341726}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15341726 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15341726}}
 ==About this Structure==
@@ Line 34: / Line 38: @@
 [[Category: Icosahedral virus]]
 [[Category: Prm particle]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 09:55:19 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:45:37 2008''