1tlz: Difference between revisions

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[[Image:1tlz.~~jpg~~|left|200px]]

[[Image:1tlz.png|left|200px]]

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~~'''~~Tsx structure complexed with uridine~~'''~~

===Tsx structure complexed with uridine===

~~==Overview==~~

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~~Tsx is a nucleoside~~-~~specific outer membrane (OM) transporter of Gram~~-negative bacteria. We present crystal structures of Escherichia coli Tsx in the absence and presence of nucleosides. These structures provide a mechanism for nucleoside transport across the bacterial OM. Tsx forms a monomeric, 12-stranded beta-barrel with a long and narrow channel spanning the outer membrane. The ~~channel, which is shaped like a keyhole, contains several distinct nucleoside-binding sites~~, ~~two of which are well defined. The base moiety of the nucleoside is located in the narrow part of the keyhole~~, ~~while~~ the ~~sugar occupies~~ the ~~wider opening~~. ~~Pairs of aromatic residues and flanking ionizable residues are involved in nucleoside binding~~. ~~Nucleoside transport presumably occurs by diffusion from one binding site to~~ the ~~next~~.

The line below this paragraph, {{ABSTRACT_PUBMED_15272310}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 15272310 is the PubMed ID number.

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==About this Structure==

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[[Category: Nucleoside transporter]]

[[Category: Uridine]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 10~~:06:55 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:53:39 2008''

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-[[Image:1tlz.jpg|left|200px]]
+{{Seed}}
+[[Image:1tlz.png|left|200px]]
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 {{STRUCTURE_1tlz|  PDB=1tlz  |  SCENE=  }}
-'''Tsx structure complexed with uridine'''
+===Tsx structure complexed with uridine===
-==Overview==
+<!--
-Tsx is a nucleoside-specific outer membrane (OM) transporter of Gram-negative bacteria. We present crystal structures of Escherichia coli Tsx in the absence and presence of nucleosides. These structures provide a mechanism for nucleoside transport across the bacterial OM. Tsx forms a monomeric, 12-stranded beta-barrel with a long and narrow channel spanning the outer membrane. The channel, which is shaped like a keyhole, contains several distinct nucleoside-binding sites, two of which are well defined. The base moiety of the nucleoside is located in the narrow part of the keyhole, while the sugar occupies the wider opening. Pairs of aromatic residues and flanking ionizable residues are involved in nucleoside binding. Nucleoside transport presumably occurs by diffusion from one binding site to the next.
+The line below this paragraph, {{ABSTRACT_PUBMED_15272310}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15272310 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15272310}}
 ==About this Structure==
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 [[Category: Nucleoside transporter]]
 [[Category: Uridine]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 10:06:55 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:53:39 2008''