1tm6: Difference between revisions

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[[Image:1tm6.gif|left|200px]]
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[[Image:1tm6.png|left|200px]]


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{{STRUCTURE_1tm6|  PDB=1tm6  |  SCENE=  }}  
{{STRUCTURE_1tm6|  PDB=1tm6  |  SCENE=  }}  


'''NMR Structure of the Free Zinc Binding C-terminal Domain of SecA'''
===NMR Structure of the Free Zinc Binding C-terminal Domain of SecA===




==Overview==
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SecA is an integral component of the prokaryotic Sec preprotein secretory translocase system. We report here the solution NMR structure of a fragment corresponding to the C-terminal domain of Escherichia coli SecA. In the presence of Zn2+, the fragment adopts a shortened version of the classic betabetaalpha zinc finger fold. The isolated C-terminal domain shows substantial differences from the X-ray structure of a homologous SecA domain bound to the chaperone-like cofactor SecB. The differences between the structures of the free and bound forms suggest that binding to SecB causes a perturbation of the C-terminal domain's intrinsically favored betabetaalpha fold.
The line below this paragraph, {{ABSTRACT_PUBMED_15488768}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_15488768}}


==About this Structure==
==About this Structure==
1TM6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TM6 OCA].  
1TM6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TM6 OCA].  


==Reference==
==Reference==
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[[Category: Seca]]
[[Category: Seca]]
[[Category: Zinc finger]]
[[Category: Zinc finger]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 10:07:20 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:20:53 2008''

Revision as of 14:20, 27 July 2008

File:1tm6.png

Template:STRUCTURE 1tm6

NMR Structure of the Free Zinc Binding C-terminal Domain of SecA

Template:ABSTRACT PUBMED 15488768

About this Structure

1TM6 is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

NMR structure of the C-terminal domain of SecA in the free state., Matousek WM, Alexandrescu AT, Biochim Biophys Acta. 2004 Nov 1;1702(2):163-71. PMID:15488768

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