9h44: Difference between revisions
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==Jumonji domain-containing protein 2B with crown ether and crystallization epitope mutations L916G:R917A:A918D== | |||
<StructureSection load='9h44' size='340' side='right'caption='[[9h44]], [[Resolution|resolution]] 1.74Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9h44]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9H44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9H44 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=O4B:1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE'>O4B</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9h44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9h44 OCA], [https://pdbe.org/9h44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9h44 RCSB], [https://www.ebi.ac.uk/pdbsum/9h44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9h44 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Damerell | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/KDM4B_HUMAN KDM4B_HUMAN] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Burgess-Brown N]] | ||
[[Category: | [[Category: Damerell D]] | ||
[[Category: | [[Category: Fairhead M]] | ||
[[Category: | [[Category: Koekemoer L]] | ||
[[Category: Krojer T]] | |||
[[Category: MacLean EM]] | |||
[[Category: Mackinnon SR]] | |||
[[Category: Marsden B]] | |||
[[Category: Pinkas D]] | |||
[[Category: Strain-Damerell C]] | |||
[[Category: Ye M]] | |||
[[Category: Yue W]] | |||
[[Category: Von Delft F]] | |||
Latest revision as of 06:22, 4 December 2024
Jumonji domain-containing protein 2B with crown ether and crystallization epitope mutations L916G:R917A:A918D
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