1toa: Difference between revisions

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[[Image:1toa.gif|left|200px]]
{{Seed}}
[[Image:1toa.png|left|200px]]


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{{STRUCTURE_1toa|  PDB=1toa  |  SCENE=  }}  
{{STRUCTURE_1toa|  PDB=1toa  |  SCENE=  }}  


'''PERIPLASMIC ZINC BINDING PROTEIN TROA FROM TREPONEMA PALLIDUM'''
===PERIPLASMIC ZINC BINDING PROTEIN TROA FROM TREPONEMA PALLIDUM===




==Overview==
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The crystal structure of recombinant TroA, a zinc-binding protein component of an ATP-binding cassette transport system in Treponema pallidum, was determined at a resolution of 1.8 A. The organization of the protein is largely similar to other periplasmic ligand-binding proteins (PLBP), in that two independent globular domains interact with each other to create a zinc-binding cleft between them. The structure has one bound zinc pentavalently coordinated to residues from both domains. Unlike previous PLBP structures that have an interdomain hinge composed of beta-strands, the N- and C-domains of TroA are linked by a single long backbone helix. This unique backbone helical conformation was possibly adopted to limit the hinge motion associated with ligand exchange.
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{{ABSTRACT_PUBMED_10404217}}


==About this Structure==
==About this Structure==
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[[Category: Periplasmic binding protein]]
[[Category: Periplasmic binding protein]]
[[Category: Zinc binding protein]]
[[Category: Zinc binding protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 10:10:54 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:26:55 2008''

Revision as of 09:27, 29 July 2008

File:1toa.png

Template:STRUCTURE 1toa

PERIPLASMIC ZINC BINDING PROTEIN TROA FROM TREPONEMA PALLIDUM

Template:ABSTRACT PUBMED 10404217

About this Structure

1TOA is a Single protein structure of sequence from Treponema pallidum. Full crystallographic information is available from OCA.

Reference

Treponema pallidum TroA is a periplasmic zinc-binding protein with a helical backbone., Lee YH, Deka RK, Norgard MV, Radolf JD, Hasemann CA, Nat Struct Biol. 1999 Jul;6(7):628-33. PMID:10404217

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