1tou: Difference between revisions

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[[Image:1tou.gif|left|200px]]
{{Seed}}
[[Image:1tou.png|left|200px]]


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{{STRUCTURE_1tou|  PDB=1tou  |  SCENE=  }}  
{{STRUCTURE_1tou|  PDB=1tou  |  SCENE=  }}  


'''Crystal structure of human adipocyte fatty acid binding protein in complex with a non-covalent ligand'''
===Crystal structure of human adipocyte fatty acid binding protein in complex with a non-covalent ligand===




==Overview==
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The synthesis and biological evaluation of novel human A-FABP inhibitors based on the 6-(trifluoromethyl)pyrimidine-4(1H)-one scaffold is described. Two series of compounds, bearing either an amino or carbon substituent in the 2-position of the pyrimidine ring were investigated. Modification of substituents and chain length optimization led to novel compounds with low micromolar activity and good selectivity for human A-FABP.
The line below this paragraph, {{ABSTRACT_PUBMED_15357970}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15357970 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15357970}}


==About this Structure==
==About this Structure==
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[[Category: Lipid-binding]]
[[Category: Lipid-binding]]
[[Category: Transport]]
[[Category: Transport]]
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